Endosc Int Open 2015; 03(06): E605-E609
DOI: 10.1055/s-0034-1393087
Original article
© Georg Thieme Verlag KG Stuttgart · New York

Early clinical experience of the safety and efficacy of EndoClot in the management of non-variceal upper gastrointestinal bleeding

Sabina Beg
Gastroenterology, West Hertfordshire Hospitals NHS Trust, Hertfordshire, United Kingdom
,
Ibrahim Al-Bakir
Gastroenterology, West Hertfordshire Hospitals NHS Trust, Hertfordshire, United Kingdom
,
Meha Bhuva
Gastroenterology, West Hertfordshire Hospitals NHS Trust, Hertfordshire, United Kingdom
,
Jay Patel
Gastroenterology, West Hertfordshire Hospitals NHS Trust, Hertfordshire, United Kingdom
,
Mark Fullard
Gastroenterology, West Hertfordshire Hospitals NHS Trust, Hertfordshire, United Kingdom
,
Anthony Leahy
Gastroenterology, West Hertfordshire Hospitals NHS Trust, Hertfordshire, United Kingdom
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Weitere Informationen

Publikationsverlauf

submitted 04. Mai 2015

accepted after revision 11. August 2015

Publikationsdatum:
27. November 2015 (online)

Background and study aims: EndoClot is a novel topical hemostatic powder approved for use in non-variceal upper gastrointestinal bleeding. This study examines its impact as rescue therapy in the management of gastrointestinal bleeding for which standard endoscopic therapy failed to achieve hemostasis.

Methods: This observational study covered a 24-month period. Data were collated from patients treated with EndoClot for comparison with a cohort of patients managed with standard endoscopic therapy. End points of this study included immediate hemostasis, 30-day rebleed rate, 30-day mortality rate, and adverse events.

Results: Between April 1, 2012, and March 31, 2014, gastroscopic procedures were performed in 1009 patients, of whom 173 required endoscopic therapy. EndoClot was used in 21 patients, with immediate hemostasis achieved in all cases, a 30-day rebleed rate of 4.8 % (95 % confidence interval [95 %CI] – 4.34 % to 3.94 %), and a 30-day mortality rate of 19.0 % (95 %CI 2.29 % – 35.91 %). Despite higher risk bleeds in this cohort of patients, Fisher's exact test demonstrated no significant difference between their 30-day mortality rate (P = 0.51) and rebleed rate (P = 0.31) and those of the patients treated with standard endoscopic hemostatic techniques.

Conclusions: This study demonstrates that EndoClot can be used both safely and effectively in the management of non-variceal upper gastrointestinal bleeding.

 
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