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Semin Neurol 2014; 34(04): 425-436
DOI: 10.1055/s-0034-1390391
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Neurologic Complications of Systemic Lupus Erythematosus, Sjögren Syndrome, and Rheumatoid Arthritis

Shamik Bhattacharyya
1   Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
2   Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts
3   Department of Neurology, Harvard Medical School, Boston, Massachusetts
,
Simon M. Helfgott
4   Department of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts
5   Department of Rheumatology, Harvard Medical School, Boston, Massachusetts
› Author Affiliations
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Publication History

Publication Date:
04 November 2014 (online)

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Abstract

Neurologic complications are frequent and often morbid in systemic lupus erythematosus, Sjögren syndrome, and rheumatoid arthritis. Although all are systemic inflammatory syndromes, each disease affects the nervous system distinctly, such as peripheral neuropathy in Sjögren syndrome, cerebrovascular disease in lupus, and cervical spine subluxation in rheumatoid arthritis. Some neurologic complications share convergent pathophysiology across diseases, such as neuromyelitis optica spectrum disorders in both Sjögren syndrome and lupus. Ill-defined cognitive complaints are especially common in lupus and Sjögren syndrome. For the majority of the complications, evidence for treatment efficacy is limited and requires further investigation.

Keywords

systemic lupus erythematosus - Sjögren syndrome - rheumatoid arthritis - cervical spine subluxation - antiphospholipid syndrome - neuromyelitis optica - myelitis - peripheral neuropathy
 

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