Diagnostische Wertigkeit der ¹⁸F-FDG-PET und MRT bei frühkindlicher Histiozytose

Zusammenfassung

Es wird in diesem Übersichtsartikel die diagnostische Wertigkeit der ¹⁸F-Fluorodeoxyglucose-Positronenemissionstomografie (¹⁸F-FDG-PET) und Magnetresonanztomografie (MRT) für die Beurteilung der frühkindlichen Histiozytose dargestellt. Dabei werden Studien verglichen, die die Genauigkeit der ¹⁸F-FDG-PET und MRT untersuchten. Es zeigt sich ein Vorteil der ¹⁸F-FDG-PET in der Beurteilung der Tumoraktivität nach Chemotherapie. Die MRT zeigt eine höhere Sensitivität bei der Primärdiagnostik sowie bei der Beurteilung des intrazerebralen Befalls. Die kombinierte PET/MRT hat das Potenzial, die Vorteile beider Modalitäten in einem Untersuchungsdurchlauf zu verbinden.

Abstract

To analyze the diagnostic value of ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) and magnetic resonance imaging for the evaluation of paediatric Langerhans cell histiocytosis. Results from different studies on the diagnostic accuracy of both modalities are compared. Our analysis suggests an important role of ¹⁸F-FDG PET for lesion follow-up after chemotherapy. MRI showed a higher sensitivity at primary diagnosis and is indispensable for evaluation of brain involvement. Simultaneous whole body PET/MRI acquisition may have the potential to combine the advantages of both modalities in one examination.

Schlüsselwörter

Histiozytose - FDG - PET - MRT - Wertigkeit

Key words

histiocytosis - FDG - PET - MRI - diagnostic value

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