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Z Gastroenterol 2015; 53(03): 235-243
DOI: 10.1055/s-0034-1385711
Kongressbericht
© Georg Thieme Verlag KG Stuttgart · New York

Gastrointestinale Stromatumoren (GIST) – Neues zu Pathologie, Chirurgie und medikamentöser Therapie

Erarbeitet im Rahmen des 10. Deutschen GIST-Treffens, GöttingenGastrointestinal Stromal Tumours (GIST) – development in pathology, surgery and medical therapyDeveloped during the 10th German GIST-meeting, Göttingen
A. Agaimy
1   Pathologie, Universität Erlangen
,
S. Bauer
2   Innere Klinik (Tumorforschung), Universitätsklinik Essen
,
A. Beham
3   Allgemein-Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen
,
J. Bertolini
4   Institut für Pathologie, Hamburg
,
F. Haller
1   Pathologie, Universität Erlangen
,
R. Koschny
5   Medizinische Klinik IV, Universität Heidelberg
,
J. Maier
6   Hämatologie und Hämostaseologie, Universität Leipzig
,
M. Montemurro
7   Sarcoma Unit, Royal Marsden Hospital, London
,
D. Perez
8   Allgemein-Viszeral- und Thoraxchirurgie, Universität Hamburg
,
I.-M. Schaefer
9   Pathology, Brigham and Women's Hospital, Boston, MA.
,
H.-U. Schildhaus
10   Pathologie, Universitätsmedizin Göttingen
,
C. Wurst
11   Allgemein- und Viszeralchirurgie, Universitätsklinikum Jena
,
S. Cameron
12   Gastroenterologie und Endokrinologie, Universitätsmedizin Göttingen
› Author Affiliations
Further Information

Publication History

09 July 2014

10 November 2014

Publication Date:
16 March 2015 (online)

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Zusammenfassung

Mit der Erstbeschreibung der Liganden-unabhängigen aktivierenden Mutationen in dem für die Tyrosinkinase KIT kodierenden Gen KIT entwickelte sich ein Verständnis für die Biologie gastrointestinaler Stromatumoren (GIST). Als „Paradigma zielgerichteter Therapie“ gab es Impulse für das Verständnis von Resistenzmechanismen und die Behandlung anderer Kinase-abhängiger Tumoren. Zum Austausch aktueller Erkenntnisse auf dem Gebiet des GIST findet seit nunmehr 10 Jahren im Dezember das deutsche GIST-Treffen traditionell in Göttingen statt. Klinische Diagnostik, Pathologie, Chirurgie und medikamentöse Therapie bilden dabei die wichtigsten Themengruppen. Die folgende Darstellung gibt eine Übersicht über die diskutierten Inhalte und Besonderheiten von GIST einschließlich aktueller Daten der verschiedenen Themengebiete.

Abstract

The first description of ligand-independent activating mutations in the KIT gene, which encodes the tyrosine-kinase KIT, greatly improved our understanding of gastrointestinal stromal tumour (GIST) biology. The therapeutic success in GIST has made tyrosine kinase inhibitors a “paradigm of targeted therapy”. Deciphering resistance mechanisms in GIST has had implications for many other kinase-driven cancers. To exchange current knowledge within the field of GIST, the German GIST Meeting has taken place for now 10 years, traditionally in Göttingen. Subjects discussed include clinical diagnostics, pathology, surgery, and medical therapy. The following presentation gives an overview of the last meeting held in December 2013, including distinctive features in GIST and current data on the different topics.

Schlüsselwörter

Gastrointestinaler Stromatumor (GIST) - Gastro-entero-pankreatische Tumoren - Magen - Darm

Key words

gastrointestinal stromal tumours (GIST) - gastro-entero-pancreatic tumours - stomach - intestines
 

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