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DOI: 10.1055/s-0034-1384640
Rapid Fecal Calprotectin (FC) Analysis: Point of Care Testing for Diagnosing Early Necrotizing Enterocolitis
Publikationsverlauf
23. März 2014
05. Juni 2014
Publikationsdatum:
11. August 2014 (online)
![](https://www.thieme-connect.de/media/ajp/201504/lookinside/thumbnails/10.1055-s-0034-1384640-1.jpg)
Abstract
Objective The aim of this study is to compare fecal calprotectin (FC) levels as measured by a rapid FC assay with those measured by enzyme-linked immunosorbent assay (ELISA) from concurrent stool samples. We also attempted to demonstrate a correlation between elevated rapid assay FC levels and the presence of necrotizing enterocolitis (NEC) and to define a cutoff FC value which could serve as a basis for diagnosing NEC in the future.
Study Design Stool samples were collected for FC analysis at 1 and 3 weeks postnatally and whenever there was clinical suspicion of NEC.
Results Rapid assay FC levels were elevated with NEC (3,000 µg/g stool [2075,7875] vs. without (195 µg/g stool [110,440] p < 0.001); and were well correlated with ELISA FC levels (r 2 = 0.89).
Conclusion We present the first data showing that rapid assay FC levels are potentially useful in the bedside diagnosis of NEC.
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