Der Einfluss von Dopamin auf neuronale Aktivitätsmuster während emotionaler Reizverarbeitung im Nucleus subthalamicus bei Parkinsonpatienten^[1]

Schlüsselwörter

Emotionsverarbeitung - Dopamin - lokale Feldpotenziale - Morbus Parkinson - Alpha- und Gamma-Oszillationen

Key words

emotional processing - dopamine - local field potentials - Parkinson’s disease - alpha and gamma oscillations

¹ Die Ergebnisse dieser Arbeit wurden erstmals publiziert als: Huebl J, Spitzer B, Brücke C, Schönecker T, Kupsch A, Alesch F, Schneider GH, Kühn AA. Oscillatory subthalamic nucleus activity is modulated by dopamine during ­emotional processing in Parkinson's ­disease. Cortex 2014 Mar 6. pii: S0010–9452 (14) 00071–9. doi:10.1016/j.cortex.2014.02.019. Die vorliegende Kurzfassung wurde durch Elsevier ­genehmigt.

• Literatur

• 1 Braak H, Del Tredici K, Rub U et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003; 24: 197-211
• 2 Chaudhuri KR, Schapira AH. Non-motor symptoms of Parkinson’s disease: dopaminergic pathophysiology and treatment. Lancet Neurol 2009; 8: 464-474
• 3 Volkmann J, Daniels C, Witt K. Neuropsychiatric effects of subthalamic neurostimulation in Parkinson disease. Nat Rev Neurol 2010; 6: 487-498
• 4 Jenkinson N, Brown P. New insights into the relationship between dopamine, beta oscillations and motor function. Trends in neurosciences 2011; 34: 611-618
• 5 Kühn AA, Kempf F, Brücke C et al. High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson’s disease in parallel with improvement in motor performance. J Neurosci 2008; 28: 6165-6173
• 6 Kühn AA, Kupsch A, Schneider GH et al. Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson’s disease. The European journal of neuroscience 2006; 23: 1956-1960
• 7 Kühn AA, Hariz MI, Silberstein P et al. Activation of the subthalamic region during emotional processing in Parkinson disease. Neurology 2005; 65: 707-713
• 8 Brücke C, Kupsch A, Schneider GH et al. The subthalamic region is activated during valence-related emotional processing in patients with Parkinson’s disease. The European journal of neuroscience 2007; 26: 767-774
• 9 Huebl J, Schoenecker T, Siegert S et al. Modulation of subthalamic alpha activity to emotional stimuli correlates with depressive symptoms in Parkinson’s disease. Mov Disord 2011; 26: 477-483
• 10 Movement Disorder Society Task Force on Rating Scales for Parkinson’s Disease . The Unified Parkinson’s Disease Rating Scale (UPDRS): status and recommendations. Mov Disord 2003; 18: 738-750
• 11 Lang PJ, Bradley MM, Cuthbert BN. International affective picture system (IAPS): Affective ratings of pictures and instruction manual. In: Gainsville, University of Florida 2008
• 12 Percival DB, Walden AT. Spectral analysis for physical applications: multitaper and conventional univariate techniques. Cambridge u. a.: Univ. Press; 1993. XXVI, 583S
• 13 Schönecker T, Kupsch A, Kuhn AA et al. Automated optimization of subcortical cerebral MR imaging-atlas coregistration for improved postoperative electrode localization in deep brain stimulation. AJNR Am J Neuroradiol 2009; 30: 1914-1921
• 14 Pfurtscheller G, Lopes da Silva FH. Event-related EEG/MEG synchronization and desynchronization: basic principles. Clin Neurophysiol 1999; 110: 1842-1857
• 15 Huebl J, Spitzer B, Brücke C et al. Oscillatory subthalamic nucleus activity is modulated by dopamine during emotional processing in Parkinson’s disease. Cortex; a journal devoted to the study of the nervous system and behavior 2014; in press
• 16 Kilner JM, Kiebel SJ, Friston KJ. Applications of random field theory to electrophysiology. Neuroscience letters 2005; 374: 174-178
• 17 Litvak V, Mattout J, Kiebel S et al. EEG and MEG data analysis in SPM8. Comput Intell Neurosci 2011; 2011: 852961
• 18 Leentjens AF, Verhey FR, Luijckx GJ et al. The validity of the Beck Depression Inventory as a screening and diagnostic instrument for depression in patients with Parkinson’s disease. Mov Disord 2000; 15: 1221-1224
• 19 Balconi M, Lucchiari C. Consciousness and arousal effects on emotional face processing as revealed by brain oscillations. A gamma band analysis. Int J Psychophysiol 2008; 67: 41-46
• 20 Keil A, Muller MM, Gruber T et al. Effects of emotional arousal in the cerebral hemispheres: a study of oscillatory brain activity and event-related potentials. Clin Neurophysiol 2001; 112: 2057-2068
• 21 Klimesch W, Fellinger R, Freunberger R. Alpha oscillations and early stages of visual encoding. Frontiers in psychology 2011; 2: 118
• 22 Klimesch W. EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain research 1999; 29: 169-195
• 23 Aftanas L, Varlamov A, Pavlov S et al. Event-related synchronization and desynchronization during affective processing: emergence of valence-related time-dependent hemispheric asymmetries in theta and upper alpha band. The International journal of neuroscience 2001; 110: 197-219
• 24 Popov T, Steffen A, Weisz N et al. Cross-frequency dynamics of neuromagnetic oscillatory activity: two mechanisms of emotion regulation. Psychophysiology 2012; 49: 1545-1557
• 25 Fumagalli M, Giannicola G, Rosa M et al. Conflict-dependent dynamic of subthalamic nucleus oscillations during moral decisions. Social neuroscience 2011; 6: 243-256
• 26 Rosa M, Fumagalli M, Giannicola G et al. Pathological gambling in Parkinson’s disease: Subthalamic oscillations during economics decisions. Mov Disord 2013;
• 27 Rodriguez-Oroz MC, Lopez-Azcarate J, Garcia-Garcia D et al. Involvement of the subthalamic nucleus in impulse control disorders associated with Parkinson’s disease. Brain 2011; 134: 36-49
• 28 Lambert C, Zrinzo L, Nagy Z et al. Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging. NeuroImage 2012; 60: 83-94
• 29 Parent A, Hazrati LN. Functional anatomy of the basal ganglia. II. The place of subthalamic nucleus and external pallidum in basal ganglia circuitry. Brain research 1995; 20: 128-154
• 30 Haegelen C, Rouaud T, Darnault P et al. The subthalamic nucleus is a key-structure of limbic basal ganglia functions. Med Hypotheses 2009;
• 31 Mink JW. The basal ganglia: focused selection and inhibition of competing motor programs. Progress in neurobiology 1996; 50: 381-425
• 32 Nambu A, Tokuno H, Takada M. Functional significance of the cortico-subthalamo-pallidal ‘hyperdirect’ pathway. Neuroscience research 2002; 43: 111-117
• 33 Peron J, Fruhholz S, Verin M et al. Subthalamic nucleus: A key structure for emotional component synchronization in humans. Neurosci Biobehav Rev 2013; 37: 358-373
• 34 Doyle LM, Kuhn AA, Hariz M et al. Levodopa-induced modulation of subthalamic beta oscillations during self-paced movements in patients with Parkinson’s disease. The European journal of neuroscience 2005; 21: 1403-1412
• 35 Lang PJ, Greenwald MK, Bradley MM et al. Looking at pictures: affective, facial, visceral, and behavioral reactions. Psychophysiology 1993; 30: 261-273
• 36 Balconi M, Pozzoli U. Arousal effect on emotional face comprehension: frequency band changes in different time intervals. Physiol Behav 2009; 97: 455-462
• 37 Oathes DJ, Ray WJ, Yamasaki AS et al. Worry, generalized anxiety disorder, and emotion: evidence from the EEG gamma band. Biol Psychol 2008; 79: 165-170
• 38 Bechara A, Tranel D, Damasio H et al. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science New York, NY 1995; 269: 1115-1118
• 39 Glascher J, Adolphs R. Processing of the arousal of subliminal and supraliminal emotional stimuli by the human amygdala. J Neurosci 2003; 23: 10274-10282
• 40 Tessitore A, Hariri AR, Fera F et al. Dopamine modulates the response of the human amygdala: a study in Parkinson’s disease. J Neurosci 2002; 22: 9099-9103
• 41 Amaral DG, Insausti R. Retrograde transport of D-[3H]-aspartate injected into the monkey amygdaloid complex. Exp Brain Res 1992; 88: 375-388
• 42 Bowers D, Miller K, Mikos A et al. Startling facts about emotion in Parkinson’s disease: blunted reactivity to aversive stimuli. Brain 2006; 129: 3356-3365
• 43 Dujardin K, Sockeel P, Devos D et al. Characteristics of apathy in Parkinson’s disease. Mov Disord 2007; 22: 778-784
• 44 Jenkinson N, Kühn AA, Brown P. Gamma oscillations in the human basal ganglia. Experimental neurology 2012;
• 45 Kempf F, Brucke C, Salih F et al. Gamma activity and reactivity in human thalamic local field potentials. The European journal of neuroscience 2009; 29: 943-953
• 46 Anzak A, Gaynor L, Beigi M et al. Subthalamic nucleus gamma oscillations mediate a switch from automatic to controlled processing: A study of random number generation in Parkinson’s disease. NeuroImage 2013; 64: 284-289
• 47 Donner TH, Siegel M. A framework for local cortical oscillation patterns. Trends in cognitive sciences 2011; 15: 191-199
• 48 Brücke C, Huebl J, Schonecker T et al. Scaling of movement is related to pallidal gamma oscillations in patients with dystonia. J Neurosci 2012; 32: 1008-1019
• 49 Engell AD, McCarthy G. Selective attention modulates face-specific induced gamma oscillations recorded from ventral occipitotemporal cortex. J Neurosci 2010; 30: 8780-8786