Semin intervent Radiol 2014; 31(03): 227-234
DOI: 10.1055/s-0034-1382789
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Percutaneous Portosystemic Shunts: TIPS and Beyond

Leigh C. Casadaban
1   Division of Interventional Radiology, Department of Radiology, University of Illinois Hospital and Health Sciences System, Chicago, Illinois
,
Ron C. Gaba
1   Division of Interventional Radiology, Department of Radiology, University of Illinois Hospital and Health Sciences System, Chicago, Illinois
› Author Affiliations
Further Information

Publication History

Publication Date:
20 August 2014 (online)

Abstract

Percutaneous interventions for portal hypertension have been available since the 1990s. Over time, improved technology—including covered stent grafts—and clinical understanding has expanded the available procedures for percutaneous portal decompression. While transjugular intrahepatic portosystemic shunt creation is the most commonly cited percutaneous intervention, direct intrahepatic portocaval shunt and percutaneous mesocaval shunt creation are important alternatives with specific advantages and applications. This article reviews contemporary, minimally invasive interventional approaches to percutaneous portosystemic shunt creation in terms of procedure rationale, patient selection, interventional technique, and technical outcomes.

 
  • References

  • 1 Jenkins RL, Gedaly R, Pomposelli JJ, Pomfret EA, Gordon F, Lewis WD. Distal splenorenal shunt: role, indications, and utility in the era of liver transplantation. Arch Surg 1999; 134 (4) 416-420
  • 2 Sarfeh IJ, Rypins EB. Partial versus total portacaval shunt in alcoholic cirrhosis. Results of a prospective, randomized clinical trial. Ann Surg 1994; 219 (4) 353-361
  • 3 Orozco H, Mercado MA, Granados Garcia J , et al. Selective shunts for portal hypertension: current role of a 21-year experience. Liver Transpl Surg 1997; 3 (5) 475-480
  • 4 Hermann RE, Henderson JM, Vogt DP, Mayes JT, Geisinger MA, Agnor C. Fifty years of surgery for portal hypertension at the Cleveland Clinic Foundation. Lessons and prospects. Ann Surg 1995; 221 (5) 459-466 , discussion 466–468
  • 5 Henderson JM, Nagle A, Curtas S, Geisinger M, Barnes D. Surgical shunts and TIPS for variceal decompression in the 1990s. Surgery 2000; 128 (4) 540-547
  • 6 Boyer TD, Haskal ZJ ; American Association for the Study of Liver Diseases. The Role of Transjugular Intrahepatic Portosystemic Shunt (TIPS) in the Management of Portal Hypertension: update 2009. Hepatology 2010; 51 (1) 306
  • 7 Runyon BA ; AASLD Practice Guidelines Committee. Management of adult patients with ascites due to cirrhosis: an update. Hepatology 2009; 49 (6) 2087-2107
  • 8 Salerno F, Cammà C, Enea M, Rössle M, Wong F. Transjugular intrahepatic portosystemic shunt for refractory ascites: a meta-analysis of individual patient data. Gastroenterology 2007; 133 (3) 825-834
  • 9 Sherlock S. Portal circulation and portal hypertension. Gut 1978; 19 (1) 70-83
  • 10 Galambos JT. Portal hypertension. Semin Liver Dis 1985; 5 (3) 277-290
  • 11 Berzigotti A, Seijo S, Reverter E, Bosch J. Assessing portal hypertension in liver diseases. Expert Rev Gastroenterol Hepatol 2013; 7 (2) 141-155
  • 12 Rössle M, Gerbes AL. TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update. Gut 2010; 59 (7) 988-1000
  • 13 Centers for Disease Control and Prevention, National Center for Health Statistics. Compressed Mortality File 1999–2010 on CDC WONDER Online Database, released January 2013. Data are compiled from Compressed Mortality File 1999–2010 Series 20 No. 2P, 2013. Available at: http://wonder.cdc.gov/cmf-icd10.html . Accessed December 9, 2013
  • 14 Runyon BA ; Practice Guidelines Committee, American Association for the Study of Liver Diseases (AASLD). Management of adult patients with ascites due to cirrhosis. Hepatology 2004; 39 (3) 841-856
  • 15 Kovalak M, Lake J, Mattek N, Eisen G, Lieberman D, Zaman A. Endoscopic screening for varices in cirrhotic patients: data from a national endoscopic database. Gastrointest Endosc 2007; 65 (1) 82-88
  • 16 D'Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol 2006; 44 (1) 217-231
  • 17 Gøtzsche PC, Hróbjartsson A. Somatostatin analogues for acute bleeding oesophageal varices. Cochrane Database Syst Rev 2008; (3) CD000193
  • 18 D'Amico G, De Franchis R ; Cooperative Study Group. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. Hepatology 2003; 38 (3) 599-612
  • 19 Warren WD. Control of variceal bleeding. Reassessment of rationale. Am J Surg 1983; 145 (1) 8-16
  • 20 Henderson JM. Distal splenorenal shunt. In: Clavien PA, Sarr MG, Fong Y, , eds. Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery. 1st ed. Heidelberg, Germany: Springer; 2007: 653-664
  • 21 Mercado MA, Orozco H. Low-diameter mesocaval shunt. In: Clavien PA, Sarr MG, Fong Y, , eds. Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery. 1st ed. Heidelberg, Germany: Springer; 2007: 665-674
  • 22 Rosemurgy AS, Korkolis DP. 8MM interposition portacaval shunt. In: Clavien PA, Sarr MG, Fong Y, , eds. Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery. 1st ed. Heidelberg, Germany: Springer; 2007: 675-686
  • 23 Orloff MJ, Orloff MS, Orloff SL. Portacaval shunts: side-to-side and end-to-side. In: Clavien PA, Sarr MG, Fong Y, , eds. Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery. 1st ed. Heidelberg, Germany: Springer; 2007: 687-702
  • 24 Khanna R, Mishra S, Khanna S, Khanna AK. Inferior meso-caval shunt for portal hypertension with bleeding esophageal varices. Indian J Gastroenterol 2003; 22 (3) 108-109
  • 25 Walser EM, Harris VM, Harman JT, Park HM, Siddiqui AR. Quantification of intrahepatic portosystemic shunting after placement of a transjugular intrahepatic portosystemic shunt. J Vasc Interv Radiol 1996; 7 (2) 263-267
  • 26 Rösch J, Hanafee WN, Snow H. Transjugular portal venography and radiologic portacaval shunt: an experimental study. Radiology 1969; 92 (5) 1112-1114
  • 27 Gordon JD, Colapinto RF, Abecassis M , et al. Transjugular intrahepatic portosystemic shunt: a nonoperative approach to life-threatening variceal bleeding. Can J Surg 1987; 30 (1) 45-49
  • 28 Richter GM, Noeldge G, Palmaz JC , et al. Transjugular intrahepatic portacaval stent shunt: preliminary clinical results. Radiology 1990; 174 (3 Pt 2) 1027-1030
  • 29 Haskal ZJ, Davis A, McAllister A, Furth EE. PTFE-encapsulated endovascular stent-graft for transjugular intrahepatic portosystemic shunts: experimental evaluation. Radiology 1997; 205 (3) 682-688
  • 30 Gaba RC, Omene BO, Podczerwinski ES , et al. TIPS for treatment of variceal hemorrhage: clinical outcomes in 128 patients at a single institution over a 12-year period. J Vasc Interv Radiol 2012; 23 (2) 227-235
  • 31 Parvinian A, Bui JT, Knuttinen MG, Minocha J, Gaba RC. Transjugular intrahepatic portosystemic shunt for the treatment of medically refractory ascites. Diagn Interv Radiol 2014; 20 (1) 58-64
  • 32 Freedman AM, Sanyal AJ, Tisnado J , et al. Complications of transjugular intrahepatic portosystemic shunt: a comprehensive review. Radiographics 1993; 13 (6) 1185-1210
  • 33 Khan S, Tudur Smith C, Williamson P, Sutton R. Portosystemic shunts versus endoscopic therapy for variceal rebleeding in patients with cirrhosis. Cochrane Database Syst Rev 2006; (4) CD000553
  • 34 Petersen B, Uchida BT, Timmermans H, Keller FS, Rosch J. Intravascular US-guided direct intrahepatic portacaval shunt with a PTFE-covered stent-graft: feasibility study in swine and initial clinical results. J Vasc Interv Radiol 2001; 12 (4) 475-486
  • 35 Petersen B, Binkert C. Intravascular ultrasound-guided direct intrahepatic portacaval shunt: midterm follow-up. J Vasc Interv Radiol 2004; 15 (9) 927-938
  • 36 Petersen BD, Clark TW. Direct intrahepatic portocaval shunt. Tech Vasc Interv Radiol 2008; 11 (4) 230-234
  • 37 Hutchins RR, Patch D, Tibballs J, Burroughs A, Davidson BR. Liver transplantation complicated by embedded transjugular intrahepatic portosystemic shunt: a new method for portal anastomosis- a surgical salvage procedure. Liver Transpl 2000; 6 (2) 237-238
  • 38 Blakemore AH, Lord JW. The Technic of Using Vitallium Tubes in Establishing Portacaval Shunts for Portal Hypertension. Ann Surg 1945; 122 (4) 476-489
  • 39 Nyman UR, Semba CP, Chang H, Hoffman C, Dake MD. Percutaneous creation of a mesocaval shunt. J Vasc Interv Radiol 1996; 7 (5) 769-773
  • 40 Scudamore CH, Erb SR, Morris C , et al. Medium aperture meso-caval shunts reliably prevent recurrent variceal hemorrhages. Am J Surg 1996; 171 (5) 490-494
  • 41 Kaminou T, Rösch J, Yamada R , et al. Percutaneous retroperitoneal splenorenal shunt: an experimental study in swine. Radiology 1998; 206 (3) 799-802
  • 42 Wang LG, Fan WJ, Zhang L, Wang B, Tang T, Li X. [Percutaneous retroperitoneal splenorenal stent shunt: an experimental study in swine model with portal hypertension]. Zhonghua Yi Xue Za Zhi 2010; 90 (17) 1216-1219
  • 43 Saab S, Nieto JM, Lewis SK, Runyon BA. TIPS versus paracentesis for cirrhotic patients with refractory ascites. Cochrane Database Syst Rev 2006; (4) CD004889
  • 44 Bilbao JI, Pueyo JC, Longo JM , et al. Interventional therapeutic techniques in Budd-Chiari syndrome. Cardiovasc Intervent Radiol 1997; 20 (2) 112-119
  • 45 Guevara M, Ginès P, Bandi JC , et al. Transjugular intrahepatic portosystemic shunt in hepatorenal syndrome: effects on renal function and vasoactive systems. Hepatology 1998; 28 (2) 416-422
  • 46 Spencer EB, Cohen DT, Darcy MD. Safety and efficacy of transjugular intrahepatic portosystemic shunt creation for the treatment of hepatic hydrothorax. J Vasc Interv Radiol 2002; 13 (4) 385-390
  • 47 García-Pagán JC, Caca K, Bureau C , et al; Early TIPS (Transjugular Intrahepatic Portosystemic Shunt) Cooperative Study Group. Early use of TIPS in patients with cirrhosis and variceal bleeding. N Engl J Med 2010; 362 (25) 2370-2379
  • 48 Garcia-Pagán JC, Di Pascoli M, Caca K , et al. Use of early-TIPS for high-risk variceal bleeding: results of a post-RCT surveillance study. J Hepatol 2013; 58 (1) 45-50
  • 49 D'Avola D, Bilbao JI, Zozaya G , et al. Efficacy of transjugular intrahepatic portosystemic shunt to prevent total portal vein thrombosis in cirrhotic patients awaiting for liver transplantation. Transplant Proc 2012; 44 (9) 2603-2605
  • 50 Rajan DK, Haskal ZJ, Clark TW. Serum bilirubin and early mortality after transjugular intrahepatic portosystemic shunts: results of a multivariate analysis. J Vasc Interv Radiol 2002; 13 (2 Pt 1) 155-161
  • 51 Valji K. Hepatic, splenic, and portal vascular systems. In: Valji K, , ed. Vascular and Interventional Radiology. 2nd ed. Philadelphia, PA: Elsevier Inc.; 2006: 269-319
  • 52 Kamath PS, Wiesner RH, Malinchoc M , et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33 (2) 464-470
  • 53 Salerno F, Merli M, Cazzaniga M , et al. MELD score is better than Child-Pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shunt. J Hepatol 2002; 36 (4) 494-500
  • 54 Schepke M, Roth F, Fimmers R , et al. Comparison of MELD, Child-Pugh, and Emory model for the prediction of survival in patients undergoing transjugular intrahepatic portosystemic shunting. Am J Gastroenterol 2003; 98 (5) 1167-1174
  • 55 Ferral H, Gamboa P, Postoak DW , et al. Survival after elective transjugular intrahepatic portosystemic shunt creation: prediction with model for end-stage liver disease score. Radiology 2004; 231 (1) 231-236
  • 56 Gaba RC, Couture PM, Bui JT , et al. Prognostic capability of different liver disease scoring systems for prediction of early mortality after transjugular intrahepatic portosystemic shunt creation. J Vasc Interv Radiol 2012; ; In press
  • 57 Scanlon T, Ryu RK. Portal vein imaging and access for transjugular intrahepatic portosystemic shunts. Tech Vasc Interv Radiol 2008; 11 (4) 217-224
  • 58 Venkatesan AM, Kundu S, Sacks D , et al; Society of Interventional Radiology Standards of Practice Committee. Practice guidelines for adult antibiotic prophylaxis during vascular and interventional radiology procedures. [corrected] J Vasc Interv Radiol 2010; 21 (11) 1611-1630 , quiz 1631
  • 59 DeGasperi A, Corti A, Corso R , et al. Transjugular intrahepatic portosystemic shunt (TIPS): the anesthesiological point of view after 150 procedures managed under total intravenous anesthesia. J Clin Monit Comput 2009; 23 (6) 341-346
  • 60 Gaba RC, Khiatani VL, Knuttinen MG , et al. Comprehensive review of TIPS technical complications and how to avoid them. AJR Am J Roentgenol 2011; 196 (3) 675-685
  • 61 Vignali C, Bargellini I, Grosso M , et al. TIPS with expanded polytetrafluoroethylene-covered stent: results of an Italian multicenter study. AJR Am J Roentgenol 2005; 185 (2) 472-480
  • 62 Maleux G, Nevens F, Wilmer A , et al. Early and long-term clinical and radiological follow-up results of expanded-polytetrafluoroethylene-covered stent-grafts for transjugular intrahepatic portosystemic shunt procedures. Eur Radiol 2004; 14 (10) 1842-1850
  • 63 Hausegger KA, Karnel F, Georgieva B , et al. Transjugular intrahepatic portosystemic shunt creation with the Viatorr expanded polytetrafluoroethylene-covered stent-graft. J Vasc Interv Radiol 2004; 15 (3) 239-248
  • 64 Jung HS, Kalva SP, Greenfield AJ , et al. TIPS: comparison of shunt patency and clinical outcomes between bare stents and expanded polytetrafluoroethylene stent-grafts. J Vasc Interv Radiol 2009; 20 (2) 180-185
  • 65 Parvinian A, Omene BO, Bui JT, Knuttinen MG, Minocha J, Gaba RC. Angiographic patterns of transjugular intrahepatic portosystemic shunt dysfunction and interventional approaches to shunt revision. J Clin Imaging Sci 2013; 3: 19
  • 66 Casado M, Bosch J, García-Pagán JC , et al. Clinical events after transjugular intrahepatic portosystemic shunt: correlation with hemodynamic findings. Gastroenterology 1998; 114 (6) 1296-1303
  • 67 Qi X, Liu L, Bai M , et al. Transjugular intrahepatic portosystemic shunt in combination with or without variceal embolization for the prevention of variceal rebleeding: a meta-analysis. J Gastroenterol Hepatol 2014; 29 (4) 688-696
  • 68 Haskal ZJ, Duszak Jr R, Furth EE. Transjugular intrahepatic transcaval portosystemic shunt: the gun-sight approach. J Vasc Interv Radiol 1996; 7 (1) 139-142
  • 69 Hoppe H, Wang SL, Petersen BD. Intravascular US-guided direct intrahepatic portocaval shunt with an expanded polytetrafluoroethylene-covered stent-graft. Radiology 2008; 246 (1) 306-314
  • 70 Hong R, Dhanani RS, Louie JD, Sze DY. Intravascular ultrasound-guided mesocaval shunt creation in patients with portal or mesenteric venous occlusion. J Vasc Interv Radiol 2012; 23 (1) 136-141
  • 71 Haskal ZJ, Rees CR, Ring EJ, Saxon R, Sacks D ; Society of Interventional Radiology Technology Assessment Committee. Reporting standards for transjugular intrahepatic portosystemic shunts. J Vasc Interv Radiol 2003; 14 (9 Pt 2) S419-S426
  • 72 Haskal ZJ, Martin L, Cardella JF , et al; Society of Interventional Radiology Standards of Practice Committee. Quality improvement guidelines for transjugular intrahepatic portosystemic shunts. J Vasc Interv Radiol 2003; 14 (9 Pt 2) S265-S270
  • 73 Henderson JM, Boyer TD, Kutner MH , et al; DIVERT Study Group. Distal splenorenal shunt versus transjugular intrahepatic portal systematic shunt for variceal bleeding: a randomized trial. Gastroenterology 2006; 130 (6) 1643-1651
  • 74 Orloff MJ, Vaida F, Haynes KS, Hye RJ, Isenberg JI, Jinich-Brook H. Randomized controlled trial of emergency transjugular intrahepatic portosystemic shunt versus emergency portacaval shunt treatment of acute bleeding esophageal varices in cirrhosis. J Gastrointest Surg 2012; 16 (11) 2094-2111
  • 75 Sommer CM, Gockner TL, Stampfl U , et al. Technical and clinical outcome of transjugular intrahepatic portosystemic stent shunt: bare metal stents (BMS) versus viatorr stent-grafts (VSG). Eur J Radiol 2012; 81 (9) 2273-2280
  • 76 Barrio J, Ripoll C, Bañares R , et al. Comparison of transjugular intrahepatic portosystemic shunt dysfunction in PTFE-covered stent-grafts versus bare stents. Eur J Radiol 2005; 55 (1) 120-124
  • 77 Burke C, Taylor AG, Ring EJ, Kerlan Jr RK. Creation of a percutaneous mesocaval shunt to control variceal bleeding in a child. Pediatr Radiol 2013; 43 (9) 1218-1220