UP602, a standardized botanical composition from Magnolia Officinalis, Morus alba and Guazumaulmifolia for weight control

Obesity is the largest and fastest growing public health problem in the developed and developing countries. There is a strong need for dietary supplements that help with weight control. The market size of products for weight management is large and there are few effective products. In these studies, we describe the beneficial effects of a standardized composition, designated UP602, comprised of Magnolia Officinalis, Morus alba, and Mutamba (Guazumaulmifolia) in the weight control and improving of metabolic biomarkers. Efficacy of UP602 (650 & 1300 mg/kg/day) was evaluated in high fat diet (HFD)-induced C57BL/6J mouse and SD rat obese models. Orlistat (40 mg/kg/day in mouse & 80 mg/kg/day in rat), a synthetic pancreatic lipase inhibitor was used as a positive control. Body weight, food intake, organ weight, fat weight, lipid profile and liver function markers from blood chemistry, and NASH (non-alcoholic steatohepatitis) scoring data were collected. In diet induced obesity (DIO) animal studies, dose-dependent less weight gain and fat weight, improved lipid profiling and NASH scores were observed in UP602 treated groups. Also, acute feed intake study was performed to show the appetite suppressor efficacy of UP602. UP602 exhibited the dose-dependent decrease of food intake in non-obese SD rat fed the high fat diet. Based on these results, UP602 could be used as a natural alternative to maintain healthy body weight. Also, the appetite related biomarker and further MOA studies will be discussed.