Planta Med 2014; 80 - PD114
DOI: 10.1055/s-0034-1382535

Antiplasmodial clerodane diterpene alkaloids from the stem bark of Polyalthia longifolia

K Annan 1, E Ekuadzi 1, C Asare 1, D Pistorius 2, L Oberer 3, BA Gyan 4, M Ofori 4
  • 1Department of Pharmacognosy, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
  • 2Natural Product Unit, Novartis Institutes for Biomedical Research, Basel 4056, Switzerland
  • 3Analytical Sciences, Novartis Institutes for Biomedical Research, Basel 4056, Switzerland
  • 4Department of Immunology, Noguchi Memorial Institute For Medical Research, University of Ghana, Legon

Two new clerodane diterpene alkaloids, named cleroda-3-ene pyrrole-15,16-dione 1 and cleroda-3-ene, pyrrolidine-15,16-dione 2, along with one known compound, bisclerodane imide 3 were isolated from the stem bark of Polyalthia longifolia var Pendula Benth. Hook. F. The isolated compounds demonstrated antiplasmodial effects with IC50's of 1.51 – 3.37 µg/ml.

Fig. 1