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Planta Med 2014; 80 - PD114
DOI: 10.1055/s-0034-1382535
DOI: 10.1055/s-0034-1382535
Antiplasmodial clerodane diterpene alkaloids from the stem bark of Polyalthia longifolia
Two new clerodane diterpene alkaloids, named cleroda-3-ene pyrrole-15,16-dione 1 and cleroda-3-ene, pyrrolidine-15,16-dione 2, along with one known compound, bisclerodane imide 3 were isolated from the stem bark of Polyalthia longifolia var Pendula Benth. Hook. F. The isolated compounds demonstrated antiplasmodial effects with IC50's of 1.51 – 3.37 µg/ml.
![](https://www.thieme-connect.de/media/plantamedica/201410/10-1055-s-0034-1382535-i071.jpg)
Fig. 1