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Planta Med 2014; 80 - PD109
DOI: 10.1055/s-0034-1382530
DOI: 10.1055/s-0034-1382530
Bioactive pimarane diterpenes from Icacina trichantha
Further to our previous report on the isolation and X-ray crystallographic structures of two 9βH-pimaranes (icacinol 2 and humirianthol 3) from the tubers of the African medicinal plant Icacina trichantha, compounds 1, 4 and 5 were obtained. Compound 1 was elucidated to be a new 17-hydroxyl derivative of icacinol. The absolute configuration was established by comparison with 2. Compounds 4 and 5 are 17-nor-9βH-pimaranes, identified to be humirianthenolide C and icacenone, respectively. All isolates displayed cytotoxic activity in the human melanoma MDA-MB-435 cells (IC50= 0.66 – 6.44µM), while 2, 3, and 4 also exhibited cytotoxicity in the human colon cancer HT-29 cells (IC50= 3.00 – 4.94µM).