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DOI: 10.1055/s-0034-1382514
Isolation and structure elucidation of bioactive leads from terrestrial plants
Epithelial cell adhesion molecule (EpCAM) has been implicated in tumor development in hepatocellular carcinoma cells (HCC). Studies have shown that EpCAM(+) HCC cells are more efficient at forming highly invasive tumors in mice than EpCAM(-) HCC cells. On this basis, a high-throughput screening assay was developed to identify specific inhibitors of EpCAM-dependent growth of hepatocellular carcinoma (HCC) cells. Investigation of the organic extracts of Mertensia paniculata and Pilostyles thurberi yielded a series of chalcones and diynenes which showed differential growth inhibition between EpCAM(+) and EpCAM(-) HCC's. The isolation, structure determination and biological activity of the compounds will be presented.
Funded by NCI Contract HHSN261200800001E