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DOI: 10.1055/s-0034-1382507
Antiproliferative and antimalarial sesquiterpene lactones from Piptocoma antillana
Bioassay-directed fractionation of an ethanol extract of the leaves and twigs of the antiproliferative plant Piptocoma antillana (Asparagaceae) afforded two new goyazensolide-type sesquiterpene lactones named piptoantilnolide A (1) and piptoantilnolide B (2), together with the known compounds 1-oxo-3,10-epoxy-8-metacriloxy-15-acetoxygermacra-2,4,11(13)-trien-6(12)-olide (3) and 5-epiisogoyazensolide (4). The structure elucidation of all compounds was carried out based on NMR and mass spectroscopic data analyses. The absolute configurations of all sesquiterpene lactones isolated were determined from their CD and NOESY NMR spectra. Compounds 1 – 4 showed potent A2780 activities, with IC50 values of 1.47± 0.5, 0.57± 0.3, 1.62± 0.05, and 1.56± 0.04 µM, respectively. They also displayed moderate antimalarial activity against Plasmodium falciparum with IC50 values of 6.17 ± 0.53, 2.19± 0.48, 8± 0.42 µM, and 9± 0.58 µM, respectively.