Planta Med 2014; 80 - PB14
DOI: 10.1055/s-0034-1382380

The use of DOSY in the structure elucidation of a Hawaiian deep water sponge metabolite

K Hagiwara 1, MK Harper-Ireland 2, C Anklin 3, M Elyasberg 4, B Clark 1, AD Wright 1
  • 1DKI-College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USA
  • 2Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 96813, USA
  • 3Bruker Biospin Corporation, 15 Fortune Drive, Billerica, MA 01821, USA
  • 4Advanced Chemistry Development, Moscow Department, 6 Akademik Bakulev St., Moscow 117513, Russian

Antioxidant and proton nmr screening of extracts derived from sponges found growing in the twilight zone around Hawaiian Island of Maui yielded an unusual compound that appears to be a conjugation between a terpene (1) and a small alkaloid (2). DOSY spectroscopy revealed that in solution the two entities exist free from one another.

Fig. 1