Synlett 2015; 26(16): 2288-2292
DOI: 10.1055/s-0034-1381060
letter
© Georg Thieme Verlag Stuttgart · New York

One-Step Synthesis of Nitriles from Acids, Esters and Amides Using DIBAL-H and Ammonium Chloride

Agnieszka Wojtkielewicz*
Institute of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, Poland   Email: jeremy@uwb.edu.pl
,
Zenon Łotowski
Institute of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, Poland   Email: jeremy@uwb.edu.pl
,
Jacek W. Morzycki
Institute of Chemistry, University of Białystok, Ciołkowskiego 1K, 15-245 Białystok, Poland   Email: jeremy@uwb.edu.pl
› Author Affiliations
Further Information

Publication History

Received: 11 June 2015

Accepted after revision: 09 August 2015

Publication Date:
03 September 2015 (online)


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Abstract

A convenient, one-step procedure is presented for the conversion of carboxylic acids or their derivatives (esters, lactones, amides) to nitriles with an aminoalane reagent prepared from diisobutylaluminum hydride (DIBAL-H) and ammonium chloride.

Supporting Information