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Synlett 2015; 26(16): 2257-2260
DOI: 10.1055/s-0034-1381055
DOI: 10.1055/s-0034-1381055
letter
Synthesis of 11C-Labelled Symmetrical Ureas via the Rapid Incorporation of [11C]CO2 into Aliphatic and Aromatic Amines
Weitere Informationen
Publikationsverlauf
Received: 14. Mai 2015
Accepted after revision: 02. Juli 2015
Publikationsdatum:
04. September 2015 (online)
![](https://www.thieme-connect.de/media/synlett/201516/lookinside/thumbnails/st-2015-d0366-l_10-1055_s-0034-1381055-1.jpg)
Abstract
An efficient method to radiolabel symmetrical [11C]ureas using 1,8-diazabicycloundec-7-ene (DBU) and cyclotron-produced [11C]CO2 has been developed. [11C]urea derivatives were obtained when aliphatic and aromatic amines were used with excellent radiochemical yields (RCYs) of over 70%. The mechanism of the reaction is proposed on the basis of control experiments. This simple and robust methodology provides a powerful tool to prepare 11C-labelled ureas previously inaccessible by existing methods and enable their utilisation for in vivo molecular imaging applications.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1381055.
- Supporting Information
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References and Notes
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