RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000083.xml
Synlett 2015; 26(13): 1804-1807
DOI: 10.1055/s-0034-1380677
DOI: 10.1055/s-0034-1380677
letter
A Novel One-Pot Method for Highly Regioselective Synthesis of Triazoloapyrimidinedicarboxylates Using Silica Sodium Carbonate
Weitere Informationen
Publikationsverlauf
Received: 18. Februar 2015
Accepted after revision: 02. April 2015
Publikationsdatum:
08. Mai 2015 (online)


Abstract
A novel synthesis of dimethyl 4,5-dihydro-5-aryl-[1,2,4]triazolo[1,5-a]pyrimidine-6,7-dicarboxylates is reported. This methodology consists of the one-pot condensation of 3-amino-1H-1,2,4-triazole, dimethyl acetylenedicarboxylate, and aryl aldehydes using silica sodium carbonate as a solid base catalyst. The use of silica sodium carbonate as a heterogeneous reusable catalyst makes this procedure mild, convenient, and environmentally benign.
Key words
4,5-dihydro-5-aryl-[1,2,4]triazolo[1,5-a]pyrimidine-6,7-dicarboxylates - 3-amino-1H-1,2,4-triazole - dimethyl acetylenedicarboxylate - aryl aldehydes - silica sodium carbonateSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380677.
- Supporting Information