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Synthesis 2015; 47(13): 1937-1943
DOI: 10.1055/s-0034-1380517
DOI: 10.1055/s-0034-1380517
paper
Synthesis of Isatins through Direct Oxidation of Indoles with IBX-SO3K/NaI
Further Information
Publication History
Received: 23 February 2015
Accepted: 09 March 2015
Publication Date:
21 April 2015 (online)


Abstract
The direct conversion of indoles into isatins is presented. The reagent mixture NaI/IBX-SO3K, containing a sulfonylated derivative of 2-iodoxybenzoic acid, was employed to trigger this oxidative process. Moreover, the synthetic route toward IBX-SO3K and the X-ray crystal structure of the title compound are described in great detail.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380517.
- Supporting Information