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Synlett 2014; 25(20): 2827-2830
DOI: 10.1055/s-0034-1379493
DOI: 10.1055/s-0034-1379493
synpacts
Lithiation of a Silyl Ether: Anionic Si→C Alkyl Migration
Further Information
Publication History
Received: 10 September 2014
Accepted after revision: 17 October 2014
Publication Date:
18 November 2014 (online)
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Abstract
This article describes a new synthetic utility of silyl ethers, the lithiation of which leads to an alkyl group migration from the silyl ether to the carbonyl group of the amide in the ortho position, forming a ketone. Additionally, the combination of the well-established anionic Fries rearrangement of lithiated carbamates to give hydroxyamides is discussed herein.
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References and Notes
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