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Synlett 2015; 26(03): 345-349
DOI: 10.1055/s-0034-1379319
DOI: 10.1055/s-0034-1379319
cluster
Copper-Catalyzed Aerobic C–H Trifluoromethylation of Phenanthrolines
Weitere Informationen
Publikationsverlauf
Received: 01. September 2014
Accepted after revision: 22. September 2014
Publikationsdatum:
21. Oktober 2014 (online)
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Abstract
Direct C–H trifluoromethylation of heterocycles is a valuable transformation. In particular, nonprecious metal-catalyzed C–H trifluoromethylation processes, which do not proceed through CF3 radical species, have been less developed. In this cluster report, a new copper-catalyzed aerobic C–H trifluoromethylation of phenanthrolines is described. This transformation affords trifluoromethylated phenanthrolines that have not been synthesized and preliminary mechanistic studies suggest that the CF3 group transfer may occur through cooperative activation.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information
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References and Notes
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For selected examples of transition-metal-catalyzed trifluromethyaltion of aromatics and related compounds, see:
For relevant studies in this group, see: