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Synthesis 2014; 46(21): 2884-2896
DOI: 10.1055/s-0034-1379216
DOI: 10.1055/s-0034-1379216
short review
Hydroaminoalkylation: Early-Transition-Metal-Catalyzed α-Alkylation of Amines
Weitere Informationen
Publikationsverlauf
Received: 21. Juli 2014
Accepted after revision: 04. September 2014
Publikationsdatum:
06. Oktober 2014 (online)
![](https://www.thieme-connect.de/media/synthesis/201421/lookinside/thumbnails/10.1055-s-0034-1379216-1.jpg)
Abstract
The recent development and progress of early-transition-metal-catalyzed C–H alkylation adjacent to nitrogen of unprotected amines with alkenes are summarized. Group 4 and 5 metal complexes are very effective for hydroaminoalkylation catalysis, an emerging atom-economic C(sp3)–C(sp3) bond formation strategy.
1 Introduction
2 Group 4 Hydroaminoalkylation Catalysis
2.1 Intramolecular Hydroaminoalkylation
2.2 Intermolecular Hydroaminoalkylation
3 Group 5 Hydroaminoalkylation Catalysis
4 Conclusions and Outlook
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For select, recent reviews on various aspects of C–H activation, see:
For previous discussion on hydroaminoalkylation, see:
For reviews on hydrohydroxyalkylation, see:
Ruthenium:
Iridium:
For zirconaziridine chemistry, see:
For a review of hydroamination, see: