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Synlett 2014; 25(18): 2531-2535
DOI: 10.1055/s-0034-1379214
DOI: 10.1055/s-0034-1379214
synpacts
A New Method for the Synthesis of 1,4-Diols: C(sp3)–H Hydroxylation Induced by Iron-Catalyzed Redox Hydration of Alkenes
Further Information
Publication History
Received: 08 August 2014
Accepted after revision: 04 September 2014
Publication Date:
15 October 2014 (online)


Abstract
A novel method for the synthesis of 1,4-diols from alkenes is presented. The reaction is the basis of iron-catalyzed redox hydration of alkenes. The second hydroxyl group is introduced by hydroxylation of an inert C–H bond. The mechanism includes a radical 1,5-hydrogen-transfer process of an intermediary alkoxy radical. In this paper, we describe how this new method has been discovered and developed.