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Synthesis 2015; 47(01): 65-70
DOI: 10.1055/s-0034-1379201
DOI: 10.1055/s-0034-1379201
paper
Highly Efficient, Environment-Friendly, One-Pot Synthesis of 2-Substituted 4-Formylimidazoles from 4-Acylaminoisoxazoles
Weitere Informationen
Publikationsverlauf
Received: 27. Juli 2014
Accepted after revision: 01. September 2014
Publikationsdatum:
30. September 2014 (online)
![](https://www.thieme-connect.de/media/synthesis/201501/lookinside/thumbnails/10.1055-s-0034-1379201-1.jpg)
Abstract
A highly efficient and environment-friendly one-pot synthesis of 2-substituted 4-formylimidazoles was accomplished. Raney nickel catalyzed hydrogenation of 4-acylaminoisoxazoles in ethanol, followed by sodium hydroxide promoted recyclization of the ring-opened intermediates, afforded the functionalized imidazoles.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
-
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