A New Route to Pyranocoumarins and Their Benzannulated Derivatives

Abstract

A new protocol based on sequential applications of three atom-economic processes viz. Claisen rearrangement, olefin isomerisation, and ring-closing diene metathesis has been developed to access a range of linear and angularly fused pyranocoumarin derivatives. Incorporation of enyne (in place of diene) metathesis and Diels–Alder reaction in the sequence has allowed the corresponding benzannulated derivatives to be prepared in good yields.

Key words

heterocycle - metathesis - rearrangement - Diels–Alder reaction - isomerization

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