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Synthesis 2014; 46(24): 3415-3422
DOI: 10.1055/s-0034-1379074
DOI: 10.1055/s-0034-1379074
paper
Pseudo Five-Component Synthesis of 3-(Hetero)arylmethyl-2,5-di(hetero)-aryl-Substituted Thiophenes via Sonogashira–Glaser Cyclization Sequence
Weitere Informationen
Publikationsverlauf
Received: 04. Juli 2014
Accepted after revision: 13. August 2014
Publikationsdatum:
17. September 2014 (online)
![](https://www.thieme-connect.de/media/synthesis/201424/lookinside/thumbnails/10.1055-s-0034-1379074-1.jpg)
Abstract
The Sonogashira–Glaser sequence combined with a microwave-assisted cyclization is a powerful tool to synthesize unsymmetrically substituted conjugated thiophenes. A variety of 3-(hetero)arylmethyl-2,5-di(hetero)aryl-substituted thiophenes could be synthesized in moderate to excellent yields using a single Pd/Cu catalyst system. The presented method is strikingly simple to perform using commercially available starting materials. The obtained trisubstituted oligothiophene derivatives are interesting molecules for materials science.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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