Synlett 2015; 26(18): 2491-2504
DOI: 10.1055/s-0034-1378873
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© Georg Thieme Verlag Stuttgart · New York

A Journey in the Catalytic Synthesis of 3-Substituted 3-Amino­oxindoles

Jin-Sheng Yu
a   Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N Zhongshan Road, Shanghai 200062, P. R. of China   Email: jzhou@chem.ecnu.edu.cn
,
Feng Zhou
a   Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N Zhongshan Road, Shanghai 200062, P. R. of China   Email: jzhou@chem.ecnu.edu.cn
,
Yun-Lin Liu
a   Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N Zhongshan Road, Shanghai 200062, P. R. of China   Email: jzhou@chem.ecnu.edu.cn
,
Jian Zhou*
a   Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N Zhongshan Road, Shanghai 200062, P. R. of China   Email: jzhou@chem.ecnu.edu.cn
b   State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China
› Author Affiliations
Further Information

Publication History

Received: 23 May 2015

Accepted after revision: 22 June 2015

Publication Date:
07 September 2015 (online)


Abstract

3-Substituted 3-aminooxindoles represent a type of privileged scaffold widely present in natural products and pharmaceutically active compounds. Thus, their efficient construction is of current interest. This account describes our efforts in the development of new strategies and reactions for facile access to this prominent framework.

1 Introduction

2 Nucleophilic Addition to Isatin Ketimines

3 Direct Amination of 3-Substituted Oxindoles

4 Substitution Reactions of 3-Hydroxyoxindoles

5 Conclusion and Outlook

 
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