Synthesis 2015; 47(21): 3315-3320
DOI: 10.1055/s-0034-1378860
paper
© Georg Thieme Verlag Stuttgart · New York

Copper(II) Triflate Catalyzed Synthesis of 2,4-Disubstituted Oxazoles from α-Diazoketones

M. Ramana Reddy
a   Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India   Email: basireddy@iict.res.in
,
G. Niranjan Reddy
a   Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India   Email: basireddy@iict.res.in
,
Umer Mehmood
b   Department of Chemical Engineering, King Fahd University of Petroleum & Minerals (KFUPM), Dhahran 31261, Kingdom of Saudi Arabia
,
Ibnelwaleed A. Hussein
b   Department of Chemical Engineering, King Fahd University of Petroleum & Minerals (KFUPM), Dhahran 31261, Kingdom of Saudi Arabia
,
S. U. Rahman
b   Department of Chemical Engineering, King Fahd University of Petroleum & Minerals (KFUPM), Dhahran 31261, Kingdom of Saudi Arabia
,
Khalil Harrabi
c   Department of Physics, King Fahd University of Petroleum & Minerals (KFUPM), Dhahran 31261, Kingdom of Saudi Arabia
,
Basireddy V. Subba Reddy*
a   Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India   Email: basireddy@iict.res.in
› Author Affiliations
Further Information

Publication History

Received: 09 February 2015

Accepted after revision: 28 May 2015

Publication Date:
21 July 2015 (online)


Abstract

A novel method is devised for the synthesis of 2,4-disubstituted oxazole derivatives via the coupling of α-diazoketones with amides using copper(II) triflate as the catalyst. The synthetic versatility of this approach is exemplified in the synthesis of an analogue of balsoxin.

Supporting Information