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Synthesis 2014; 46(24): 3394-3398
DOI: 10.1055/s-0034-1378664
DOI: 10.1055/s-0034-1378664
paper
Facile and Convenient Synthesis of N′1,N′3-Dialkyl-N′1,N′3-bis(arylcarbonothioyl)malonohydrazides via Propylphosphonic Anhydride Coupling
Weitere Informationen
Publikationsverlauf
Received: 26. Juni 2014
Accepted after revision: 01. August 2014
Publikationsdatum:
11. September 2014 (online)
![](https://www.thieme-connect.de/media/synthesis/201424/lookinside/thumbnails/10.1055-s-0034-1378664-1.jpg)
Dedicated to Professor Chengye Yuan and Professor Li-Xin Dai of the Shanghai Institute of Organic Chemistry (CAS) on the occasion of their 90th birthdays
Abstract
A facile and convenient synthetic method for the anticancer agent elesclomol and its analogues, N′1,N′3-dialkyl-N′1,N′3-bis(arylcarbonothioyl)malonohydrazides, by the direct coupling of N-alkyl-N-(substituted)benzothiohydrazides and substituted malonic acids using propylphosphonic anhydride (T3P®) under very mild conditions has been developed.
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For general reviews and references on T3P®, see: