Synlett 2014; 25(14): 1991-1996
DOI: 10.1055/s-0034-1378395
letter
© Georg Thieme Verlag Stuttgart · New York

A Detour Route for meta Functionalization of Phenols

Santhosh Kumar Chittimalla*
AMRI Singapore Research Centre, 61 Science Park Road, #05-01 The Galen, Science Park III, Singapore 117525, Singapore   Fax: +6563985511   eMail: santhosh.chittimalla@amriglobal.com   eMail: chemcsk@gmail.com
,
Rajesh Kuppusamy
AMRI Singapore Research Centre, 61 Science Park Road, #05-01 The Galen, Science Park III, Singapore 117525, Singapore   Fax: +6563985511   eMail: santhosh.chittimalla@amriglobal.com   eMail: chemcsk@gmail.com
,
Chennakesavulu Bandi
AMRI Singapore Research Centre, 61 Science Park Road, #05-01 The Galen, Science Park III, Singapore 117525, Singapore   Fax: +6563985511   eMail: santhosh.chittimalla@amriglobal.com   eMail: chemcsk@gmail.com
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Publikationsverlauf

Received: 15. Mai 2014

Accepted after revision: 10. Juni 2014

Publikationsdatum:
16. Juli 2014 (online)


Abstract

Cyclohexadienones participate in a two-step procedure, a Michael addition followed by aromatization, providing hitherto difficult-to-synthesize meta-functionalized phenol derivatives in good yield. Application of the developed approach is exemplified by synthesizing C-aryl acetophenones, C-aryl glycines, and elemicin – an allylphenol natural product.

Supporting Information

 
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