Recent Advances in Electrophilic Amination Reactions

Abstract

Electrophilic nitrogen sources are an increasingly popular class of reagents for the formation of C–N bonds. Recently, a significant number of useful methodologies have been reported, in particular, examples using transition-metal catalysis. This review summarizes the latest developments in this field, with a focus on very recent advances.

1 Introduction

2 Reactions with Stoichiometric Organometallic Reagents

2.1 Organoboron Nucleophiles

2.2 Zirconium Derivatives

2.3 Silicon Derivatives

2.4 Grignard Reagents

2.5 Organozinc Reagents

3 Catalytic Organometallic Species

3.1 C–H Activation Reactions

3.2 Heterocycle Synthesis via Addition/Amination Sequences

3.3 Narasaka–Heck (or Amino-Heck) Reactions

4 Enolates as Nucleophiles

5 Conclusion

Key words

amination - catalysis - heterocycles - C–H activation - organometallic reagents

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