Synlett 2014; 25(14): 2009-2012
DOI: 10.1055/s-0034-1378354
letter
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed Oxidative Electrophilic Carbofunctionalization of Acrylamides for the Synthesis of Oxindoles

Xueqin Li
a   Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, P. R. of China   Fax: +86(592)2185780   eMail: t12g21@xmu.edu.cn
,
Jian Xu
a   Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, P. R. of China   Fax: +86(592)2185780   eMail: t12g21@xmu.edu.cn
,
Pengbo Zhang
a   Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, P. R. of China   Fax: +86(592)2185780   eMail: t12g21@xmu.edu.cn
,
Yuzhen Gao
a   Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, P. R. of China   Fax: +86(592)2185780   eMail: t12g21@xmu.edu.cn
,
Ju Wu
a   Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, P. R. of China   Fax: +86(592)2185780   eMail: t12g21@xmu.edu.cn
,
Guo Tang*
a   Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, P. R. of China   Fax: +86(592)2185780   eMail: t12g21@xmu.edu.cn
,
Yufen Zhao
a   Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, P. R. of China   Fax: +86(592)2185780   eMail: t12g21@xmu.edu.cn
b   Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China
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Publikationsverlauf

Received: 05. April 2014

Accepted after revision: 27. Mai 2014

Publikationsdatum:
28. Juli 2014 (online)


Abstract

A novel and efficient copper-catalyzed tandem oxidative cyclization of arylacrylamides with diaryliodonium salts is reported. This reaction provides a novel approach for the synthesis of oxindoles and various functional groups were well tolerated.

Supporting Information