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Synlett 2014; 25(13): 1926-1936
DOI: 10.1055/s-0034-1378329
DOI: 10.1055/s-0034-1378329
letter
Synthesis of Pentasubstituted Pyrroles via Catalyst-Free Multicomponent Reactions
Weitere Informationen
Publikationsverlauf
Received: 14. März 2014
Accepted after revision: 23. Mai 2014
Publikationsdatum:
10. Juli 2014 (online)
![](https://www.thieme-connect.de/media/synlett/201413/lookinside/thumbnails/10.1055-s-0034-1378329-1.jpg)
Abstract
A facile and versatile catalyst-free method for the preparation of a wide range of pentasubstituted pyrroles has been reported using four-component reactions of arylglyoxal monohydrate, β-keto esters, amines, and various cyclic 1,3-dicarbonyls under mild reaction conditions. Employing this methodology, pseudo seven-component reactions have also been achieved in the case of p-phenylenediamine to provide conjugated bispyrroles with arene spacers.
Key words
multicomponent reactions - β-keto esters - arylglyoxals - cyclic 1,3-dicarbonyls - pentasubstituted pyrrolesSupporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
- Supporting Information
-
References and Notes
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