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DOI: 10.1055/s-0034-1377767
A new technique for delivering a polyglycolic acid sheet to cover a large mucosal defect: the Swiss roll method
Publication History
Publication Date:
19 November 2014 (online)
![](https://www.thieme-connect.de/media/endoscopy/2014S01/lookinside/thumbnails/10.1055-s-0034-1377767-1.jpg)
Endoscopic tissue shielding with polyglycolic acid (PGA) sheets (Neoveil; Gunze Co., Kyoto, Japan) and fibrin glue (Beriplast P CombiSet; CSL Behring Pharma, Tokyo, Japan) is a promising method for preventing postoperative complications [1] [2] [3]. However, this technique is thought to be inefficient for covering large mucosal defects because it takes time to deliver many small PGA sheets. Accordingly, we devised and implemented a new technique involving the delivery of a single large PGA sheet.
A 25-year-old woman with familial adenomatous polyposis was treated using a standard-caliber endoscope by rectal piecemeal endoscopic mucosal resection, leaving a large mucosal defect ([Fig. 1]). For our new technique, we used a PGA sheet and its accompanying plastic packaging sheet. We cut the PGA sheet to cover the artificial ulcer, and then we cut the plastic sheet to a slightly smaller size. We attached one edge of the plastic sheet to a small-caliber endoscope with tape. Next, we placed the PGA sheet over the plastic sheet, and we proceeded to roll the two layers around the small-caliber endoscope like a Swiss roll, making sure the PGA sheet was on the outside. We placed the enwrapped small-caliber endoscope inside an overtube (Flexible Overtube; Sumitomo Bakelite Inc., Tokyo, Japan) to prevent contact with any moisture.
![](https://www.thieme-connect.de/media/endoscopy/2014S01/thumbnails/10-1055-s-0034-1377767-i945cl1.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)
We delivered the second endoscope within the overtube to the ulcer and then removed the overtube. Using the biopsy forceps of the standard-caliber endoscope, we grasped one end of the PGA sheet ([Fig. 2 a]) and fixed it to one edge of the ulcer with clips ([Fig. 2 b]). We proceeded to unroll the PGA sheet over the ulcer ([Fig. 2 c]). The plastic sheet underneath gradually separated from the PGA sheet and remained curled around the small-caliber endoscope. We then fixed the PGA sheet using several clips ([Fig. 2 d]). This technique can be used to achieve the delivery of a single large PGA sheet to cover a sizeable mucosal defect.
![](https://www.thieme-connect.de/media/endoscopy/2014S01/thumbnails/10-1055-s-0034-1377767-i945cl2.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)
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References
- 1 Takimoto K, Toyonaga T, Matsuyama K. Endoscopic tissue shielding to prevent delayed perforation associated with endoscopic submucosal dissection for duodenal neoplasms. Endoscopy 2012; 44: E414-E415
- 2 Tsuji Y, Ohata K, Gunji T et al. Endoscopic tissue shielding method with polyglycolic acid sheets and fibrin glue to cover wounds after colorectal endoscopic submucosal dissection (with video). Gastrointest Endosc 2014; 79: 151-155
- 3 Ono S, Tsuji Y, Fujishiro M et al. An effective technique for delivery of polyglycolic acid sheet after endoscopic submucosal dissection of the esophagus: the clip and pull method. Endoscopy 2014; 46: E44-E45