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DOI: 10.1055/s-0034-1376186
Purpura Fulminans and Late Onset Group B Streptococcal Sepsis in a Premature Twin
Publikationsverlauf
14. Januar 2014
20. März 2014
Publikationsdatum:
10. Juni 2014 (online)
![](https://www.thieme-connect.de/media/ajpr/201402/lookinside/thumbnails/10.1055-s-0034-1376186-1.jpg)
Abstract
Introduction: Purpura fulminans (PF) is a skin manifestation due to hemorrhagic infarction caused by intravascular thrombosis secondary to bacterial infections or deficiency of anticoagulants such as protein C and protein S. Neonatal PF is a rare but potentially disabling disorder associated with a high mortality and severe long term morbidity in those who survive.
Case description: We report a case of a premature infant who developed extensive PF due to late onset group B streptococcus sepsis. Despite early identification and initiation of antibiotic therapy in our patient, PF progressed rapidly, leading to autoamputation of fingers and toes and severe brain injury.
Conclusion: In conclusion, our case highlights the severe sequelae of PF due to late onset GBS sepsis in a premature infant.
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References
- 1 Lynn NJ, Pauly TH, Desai NS. Purpura fulminans in three cases of early-onset neonatal group B streptococcal meningitis. J Perinatol 1991; 11 (2) 144-146
- 2 Hon KL, So KW, Wong W, Cheung KL. Spot diagnosis: An ominous rash in a newborn. Ital J Pediatr 2009; 35 (1) 10
- 3 Zenciroglu A, Karagol BS, Ipek MS, Okumus N, Yarali N, Aydin M. Neonatal purpura fulminans secondary to group B streptococcal infection. Pediatr Hematol Oncol 2010; 27 (8) 620-625
- 4 Albarrak M, Al-Matary A. Neonatal purpura fulminans manifestation in early-onset group B Streptococcal infection. Am J Case Rep 2013; 14: 315-317
- 5 Issacman SH, Heroman WM, Lightsey AL. Purpura fulminans following late-onset group B beta-hemolytic streptococcal sepsis. Am J Dis Child 1984; 138 (10) 915-916
- 6 Stewart FJ, McClure BG, Mayne E. Successful treatment of neonatal purpura fulminans with epoprostenol. J R Soc Med 1991; 84 (10) 623-624
- 7 Church J, Haram NH, Jones I, Hartnoll G. Purpura fulminans in an acute preterm neonate. Arch Dis Child Fetal Neonatal Ed 2013; 98 (1) F76-F77
- 8 Marlar RA, Neumann A. Neonatal purpura fulminans due to homozygous protein C or protein S deficiencies. Semin Thromb Hemost 1990; 16 (4) 299-309
- 9 Phares CR, Lynfield R, Farley MM , et al; Active Bacterial Core surveillance/Emerging Infections Program Network. Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005. JAMA 2008; 299 (17) 2056-2065
- 10 Bohnsack JF, Whiting A, Gottschalk M , et al. Population structure of invasive and colonizing strains of Streptococcus agalactiae from neonates of six U.S. Academic Centers from 1995 to 1999. J Clin Microbiol 2008; 46 (4) 1285-1291
- 11 Martins ER, Andreu A, Correia P , et al; Microbiologist Group for the Study of Vertical Transmission Infections from the Catalan Society for Clinical Microbiology and Infectious Diseases. Group B streptococci causing neonatal infections in barcelona are a stable clonal population: 18-year surveillance. J Clin Microbiol 2011; 49 (8) 2911-2918