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Am J Perinatol 2015; 32(03): 219-224
DOI: 10.1055/s-0034-1374816
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Impact of Neonatal Factors and Nutrition on Kidney Size in 5-Year-Old Preterm-Born Children

Sorana C. Galu
1   Neonatal Department, Maternite Regionale Universitaire, Nancy, France
,
Jean-Michel Hascoet
1   Neonatal Department, Maternite Regionale Universitaire, Nancy, France
,
Rachel Vieux
1   Neonatal Department, Maternite Regionale Universitaire, Nancy, France
2   Paediatric Nephrology Unit, CHU Nancy, Paediatric Nephrology Unit, Vandoeuvre-lès-Nancy, France
3   EA 4360 APEMAC, Université de Lorraine, Vandoeuvre-lès-Nancy, Nancy, France
› Author Affiliations
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Publication History

24 September 2013

17 March 2014

Publication Date:
24 June 2014 (online)

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Abstract

Objective The aim of this article is to evaluate the influence of neonatal factors on kidney size in 5-year-old preterm-born children.

Study design Preterm-born children were examined at 5 years with kidney ultrasound.

Result A total of 20 children were evaluated. Their gestational age (GA) was 29.3 ± 1.5 weeks, birth weight 1,321 ± 323 g. On Day 28, protein intake was (median, range) 2.8 (1.7–3.6 g/kg) g/kg, protein/total calories ratio 2.8 (range, 1.7–3.3 g/100 kcal) g/100 kcal. At 5 years, their systolic blood pressure was 97 mm Hg (range, 84–115 mm Hg). All had normal estimated glomerular filtration rate. Protein intake on Day 28 and protein/calories ratio on Day 28 were associated with a low total relative renal volume, respectively, β =  − 37 ± 15, p = 0.03; β =  − 50 ± 19, p = 0.03, after adjustment on GA, neonatal morbidities, and body mass index (multivariate linear regression). Kidney size was not associated with protein intake at 5 years.

Conclusion Improving protein prescription in the neonatal period could have an impact on kidney size in childhood in preterm-born children.

Keywords

nutrition - neonates - kidney - very low birth weight

Note

Authors did not receive financial support or equipments for this work.


 

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