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Aktuelle Rheumatologie 2016; 41(06): 488-491
DOI: 10.1055/s-0034-1374605
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Related to Inflammation Markers and Anti-CCP in Rheumatoid Arthritis

Mittleres Thrombozytenvolumen und Neutrophilen-Lymphozyten-Ratio in Bezug zu Entzündungsmarkern und Anti-CCP bei rheumatoider Arthritis
F. Gökmen
1   Canakkale Onsekiz Mart University, Medical School, Department of Physical Medicine and Rehabilitation, Canakkale, Turkey
,
A. Akbal
1   Canakkale Onsekiz Mart University, Medical School, Department of Physical Medicine and Rehabilitation, Canakkale, Turkey
,
H. Reşorlu
1   Canakkale Onsekiz Mart University, Medical School, Department of Physical Medicine and Rehabilitation, Canakkale, Turkey
,
E. Binnetoğlu
2   Canakkale Onsekiz Mart University, Medical School, Department of Internal Medicine, Canakkale, Turkey
,
S. Cevizci
3   Canakkale Onsekiz Mart University, Medical School, Public Health, Canakkale, Turkey
,
E. Gökmen
4   Canakkale State Hospital, Department of Internal Medicine, Canakkale, Turkey
,
M. M. Köse
5   Medipol University, Medical School, Department of Physical Medicine and Rehabilitation, Canakkale, Turkey
,
A. K. Türkyılmaz
6   Recep Tayyip Erdogan University, Medical School, Department of Physical Medicine and Rehabilitation, Rize, Turkey
,
E. Akbal
7   Canakkale Onsekiz Mart University, Medical School, Department of Gastroenterology, Canakkale, Turkey
› Author Affiliations
Further Information

Publication History

Publication Date:
07 July 2014 (online)

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Abstract

Background: Various thrombocyte markers and white blood cell levels and their subtypes have recently been investigated in association with inflammation. The purpose of this study was to determine the correlation of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with disease activation and clinical para­meters in rheumatoid arthritis (RA) patients.

Methods: 84 RA patients and 60 healthy controls were included. Platelet, MPV, white cell, neutrophil and lymphocyte levels in full blood counts were investigated, and NLR was calculated. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), disease activation score (DAS 28) and a health assessment questionnaire (HAQ) were used in the evaluation of RA.

Results: In the present study a total of 144 patients was enrolled, 84 with RA and 60 healthy individuals. 75.2% (n=108) were women and 24.8% (n=36) were men. The patients with RA had lower MPV than control individuals (MPV; 8.52±1.15 fL and 8.92±0.87 fL, respectively) and CRP (r:−0.234, p=0.005). RA patients’ mean NLR was significantly higher than that of the control group (2.74±1.74 and 1.80±0.78, respectively; p<0.001). Furthermore, anti-CCP positive patients had higher NLR than anti-CCP negative patients (NLR; 2.51±1.92 and 1.95±1.22, p=0.019 respectively). NLR was positively correlated with ESR (r=0.190, p=0.023), CRP (r=0.230, p=0.035) and anti-CCP (r=0.300, p=0.005).

Conclusion: In conclusion, MPV and NLR together with acute phase reactants can be a useful index for showing inflammation in RA patients.

Zusammenfassung

Einleitung: Verschiedene thrombozytäre Marker und Grenzwerte von Leukozyten und ihren Subtypen sind in der jüngeren Vergangenheit bezüglich ihres Zusammenhangs mit Entzündung untersucht worden. Ziel dieser Untersuchung war die Korrelation des mittleren Thrombozytenvolumens (MPV) und der Neutrophilen/Lymphozyten Ratio (NLR) mit der Krankheitsaktivität und klinischen Parametern bei Patienten mit rheumatoider Arthritis (RA).

Methoden: 84 RA Patienten und 60 gesunde Kontrollen wurden eingeschlossen. Aus dem Blutbild wurden Thrombozyten, MPV, Leukozyten-, Neutrophilen- und Lymphozytenwerte untersucht und die NLR errechnet. Die Erythrozytensedimentationsrate (ESR), C-reaktives Protein, Rheumafaktor (RF), anti-zyklisches citrullinieres Peptid (anti-CCP), der Krankheits­aktivität-Score DAS 28 und ein Gesundheitsbewertungsbogen (HAQ) wurden für die Bewertung der RA herangezogen.

Ergebnis: In die vorliegende Studie wurden 144 Patienten eingeschlossen, 84 mit RA und 60 gesunde Kontrollen. 75,2% (n=108) waren Frauen und 24,8% (n=36) waren Männer. Patienten mit RA hatten ein niedrigeres MPV als die Kontrollen (MPV; 8,52±1,15 fL bzw. 8,92±0,87 fL) und CRP (r:−0,234, p=0,005). Die mittlere NLR von RA Patienten war signifikant höher als die der Kontrollgruppe (2,74±1,74 bzw. 1,80±0,78; p<0,001). Außerdem hatten anti-CCP positive Patienten höhere NLRs als anti-CCP negative Patienten (NLR; 2,51±1,92 bzw. 1,95±1,22 p=0,019). Die NLR korrelierte positiv mit der ESR (r=0,190, p=0,023), dem CRP (r=0,230, p=0,035) und dem anti-CCP (r=0,300, p=0,005).

Schlussfolgerung: MPV und NLR können gemeinsam mit Akutphase-Proteinen ein hilfreicher Index für die Entzündungsaktivität bei RA Patienten sein.

Key words

rheumatoid arthritis - mean platelet volume - neutrophil-to-lymphocyte ratio - inflammation

Schlüsselwörter

Rheumatoide Arthritis - Mittlere Plättchenvolumen - Neutrophilen-to-­Lymphozyten-Verhältnis - Entzündung
 

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