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DOI: 10.1055/s-0034-1372430
Diagnosis and Treatment of Fetal Arrhythmia
Publication History
07 January 2014
10 February 2014
Publication Date:
23 May 2014 (online)
Abstract
Aims Detection and careful stratification of fetal heart rate (FHR) is extremely important in all pregnancies. The most lethal cardiac rhythm disturbances occur during apparently normal pregnancies where FHR and rhythm are regular and within normal or low-normal ranges. These hidden depolarization and repolarization abnormalities, associated with genetic ion channelopathies cannot be detected by echocardiography, and may be responsible for up to 10% of unexplained fetal demise, prompting a need for newer and better fetal diagnostic techniques. Other manifest fetal arrhythmias such as premature beats, tachycardia, and bradycardia are commonly recognized.
Methods Heart rhythm diagnosis in obstetrical practice is usually made by M-mode and pulsed Doppler fetal echocardiography, but not all fetal cardiac time intervals are captured by echocardiographic methods.
Results and Conclusions This article reviews different types of fetal arrhythmias, their presentation and treatment strategies, and gives an overview of the present and future diagnostic techniques.
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References
- 1 Oudijk MA. Fetal Tachycardia: Diagnosis and Treatment and the Fetal QT Interval in Hypoxia. Utrecht, The Netherlands: Dong UMC, Neoventa Medical AB, Stiefel; 2003: 216
- 2 Dubin AM, Cuneo BF, Strasburger JF, Wakai RT, Van Hare GF, Rosenthal DN. Congenital junctional ectopic tachycardia and congenital complete atrioventricular block: a shared etiology?. Heart Rhythm 2005; 2 (3) 313-315
- 3 Zhao H, Cuneo BF, Strasburger JF, Huhta JC, Gotteiner NL, Wakai RT. Electrophysiological characteristics of fetal atrioventricular block. J Am Coll Cardiol 2008; 51 (1) 77-84
- 4 Cuneo BF, Strasburger JF, Niksch A, Ovadia M, Wakai RT. An expanded phenotype of maternal SSA/SSB antibody-associated fetal cardiac disease. J Matern Fetal Neonatal Med 2009; 22 (3) 233-238
- 5 Strasburger JF, Wakai RT. Fetal cardiac arrhythmia detection and in utero therapy. Nat Rev Cardiol 2010; 7 (5) 277-290
- 6 Cuneo BF, Strasburger JF, Wakai RT. Magnetocardiography in the evaluation of fetuses at risk for sudden cardiac death before birth. J Electrocardiol 2008; 41 (2) e1-e6
- 7 Zhao H, Strasburger JF, Cuneo BF, Wakai RT. Fetal cardiac repolarization abnormalities. Am J Cardiol 2006; 98 (4) 491-496
- 8 Schwartz PJ. Stillbirths, sudden infant deaths, and long-QT syndrome: puzzle or mosaic, the pieces of the Jigsaw are being fitted together. Circulation 2004; 109 (24) 2930-2932
- 9 Rein AJ, O'Donnell C, Geva T , et al. Use of tissue velocity imaging in the diagnosis of fetal cardiac arrhythmias. Circulation 2002; 106 (14) 1827-1833
- 10 Cuneo BF, Strasburger JF, Yu S , et al. In utero diagnosis of long QT syndrome by magnetocardiography. Circulation 2013; 128 (20) 2183-2191
- 11 Wiggins DL, Strasburger JF, Gotteiner NL, Cuneo B, Wakai RT. Magnetophysiologic and echocardiographic comparison of blocked atrial bigeminy and 2:1 atrioventricular block in the fetus. Heart Rhythm 2013; 10 (8) 1192-1198
- 12 Kähler C, Schleussner E, Grimm B , et al. Fetal magnetocardiography in the investigation of congenital heart defects. Early Hum Dev 2002; 69 (1–2) 65-75
- 13 Devoe LD. Fetal ECG analysis for intrapartum electronic fetal monitoring: a review. Clin Obstet Gynecol 2011; 54 (1) 56-65
- 14 Vayssière C, David E, Meyer N , et al. A French randomized controlled trial of ST-segment analysis in a population with abnormal cardiotocograms during labor. Am J Obstet Gynecol 2007; 197 (3) e1-e6
- 15 Ojala K, Vääräsmäki M, Mäkikallio K, Valkama M, Tekay A. A comparison of intrapartum automated fetal electrocardiography and conventional cardiotocography—a randomised controlled study. BJOG 2006; 113 (4) 419-423
- 16 Westerhuis ME, Visser GH, Moons KG , et al. Cardiotocography plus ST analysis of fetal electrocardiogram compared with cardiotocography only for intrapartum monitoring: a randomized controlled trial. Obstet Gynecol 2010; 115 (6) 1173-1180
- 17 Nii M, Hamilton RM, Fenwick L, Kingdom JC, Roman KS, Jaeggi ET. Assessment of fetal atrioventricular time intervals by tissue Doppler and pulse Doppler echocardiography: normal values and correlation with fetal electrocardiography. Heart 2006; 92 (12) 1831-1837
- 18 Nii M, Roman KS, Kingdom J, Redington AN, Jaeggi ET. Assessment of the evolution of normal fetal diastolic function during mid and late gestation by spectral Doppler tissue echocardiography. J Am Soc Echocardiogr 2006; 19 (12) 1431-1437
- 19 Gardiner HM, Belmar C, Pasquini L , et al. Fetal ECG: a novel predictor of atrioventricular block in anti-Ro positive pregnancies. Heart 2007; 93 (11) 1454-1460
- 20 Taylor MJ, Smith MJ, Thomas M , et al. Non-invasive fetal electrocardiography in singleton and multiple pregnancies. BJOG 2003; 110 (7) 668-678
- 21 Taylor MJ, Thomas MJ, Smith MJ , et al. Non-invasive intrapartum fetal ECG: preliminary report. BJOG 2005; 112 (8) 1016-1021
- 22 Velayo C, Sato N, Ito T , et al. Understanding congenital heart defects through abdominal fetal electrocardiography: case reports and clinical implications. J Obstet Gynaecol Res 2011; 37 (5) 428-435
- 23 Dancea A, Fouron JC, Miró J, Skoll A, Lessard M. Correlation between electrocardiographic and ultrasonographic time-interval measurements in fetal lamb heart. Pediatr Res 2000; 47 (3) 324-328
- 24 Pasquini L, Seale AN, Belmar C , et al. PR interval: a comparison of electrical and mechanical methods in the fetus. Early Hum Dev 2007; 83 (4) 231-237
- 25 Horigome H, Takahashi MI, Asaka M, Shigemitsu S, Kandori A, Tsukada K. Magnetocardiographic determination of the developmental changes in PQ, QRS and QT intervals in the foetus. Acta Paediatr 2000; 89 (1) 64-67
- 26 Leuthold A, Wakai RT, Martin CB. Noninvasive in utero assessment of PR and QRS intervals from the fetal magnetocardiogram. Early Hum Dev 1999; 54 (3) 235-243
- 27 Lowery CL, Campbell JQ, Wilson JD , et al. Noninvasive antepartum recording of fetal S-T segment with a newly developed 151-channel magnetic sensor system. Am J Obstet Gynecol 2003; 188 (6) 1491-1496 , discussion 1496–1497
- 28 van Leeuwen P, Schiermeier S, Lange S , et al. Gender-related changes in magnetocardiographically determined fetal cardiac time intervals in intrauterine growth retardation. Pediatr Res 2006; 59 (6) 820-824
- 29 Comani S, Alleva G. Fetal cardiac time intervals estimated on fetal magnetocardiograms: single cycle analysis versus average beat inspection. Physiol Meas 2007; 28 (1) 49-60
- 30 Horigome H, Ogata K, Kandori A , et al. Standardization of the PQRST waveform and analysis of arrhythmias in the fetus using vector magnetocardiography. Pediatr Res 2006; 59 (1) 121-125
- 31 Kähler C, Schleussner E, Grimm B , et al. Fetal magnetocardiography: development of the fetal cardiac time intervals. Prenat Diagn 2002; 22 (5) 408-414
- 32 Quinn A, Weir A, Shahani U, Bain R, Maas P, Donaldson G. Antenatal fetal magnetocardiography: a new method for fetal surveillance?. Br J Obstet Gynaecol 1994; 101 (10) 866-870
- 33 Stinstra J, Golbach E, van Leeuwen P , et al. Multicentre study of fetal cardiac time intervals using magnetocardiography. BJOG 2002; 109 (11) 1235-1243
- 34 Van Leeuwen P, Lange S, Klein A, Geue D, Grönemeyer DH. Dependency of magnetocardiographically determined fetal cardiac time intervals on gestational age, gender and postnatal biometrics in healthy pregnancies. BMC Pregnancy Childbirth 2004; 4 (1) 6
- 35 van Leeuwen P, Lange S, Klein A , et al. Reproducibility and reliability of fetal cardiac time intervals using magnetocardiography. Physiol Meas 2004; 25 (2) 539-552
- 36 Van Leeuwen P, Lange S, Geue D, Grönemeyer D. Heart rate variability in the fetus: a comparison of measures. Biomed Tech (Berl) 2007; 52 (1) 61-65
- 37 Wakai RT, Leuthold AC, Martin CB. Atrial and ventricular fetal heart rate patterns in isolated congenital complete heart block detected by magnetocardiography. Am J Obstet Gynecol 1998; 179 (1) 258-260
- 38 Wakai RT, Wang M, Leuthold AC, Martin CB. Foetal magnetocardiogram amplitude oscillations associated with respiratory sinus arrhythmia. Physiol Meas 1995; 16 (1) 49-54
- 39 Cuneo BF, Ovadia M, Strasburger JF , et al. Prenatal diagnosis and in utero treatment of torsades de pointes associated with congenital long QT syndrome. Am J Cardiol 2003; 91 (11) 1395-1398
- 40 Fukushima A, Nakai K, Matsumoto A, Strasburger J, Sugiyama T. Prenatal diagnosis of polymorphic ventricular tachycardia using 64-channel magnetocardiography. Heart Vessels 2010; 25 (3) 270-273
- 41 Hamada H, Horigome H, Asaka M , et al. Prenatal diagnosis of long QT syndrome using fetal magnetocardiography. Prenat Diagn 1999; 19 (7) 677-680
- 42 Horigome H, Iwashita H, Yoshinaga M, Shimizu W. Magnetocardiographic demonstration of torsade de pointes in a fetus with congenital long QT syndrome. J Cardiovasc Electrophysiol 2008; 19 (3) 334-335
- 43 Menéndez T, Achenbach S, Beinder E , et al. Prenatal diagnosis of QT prolongation by magnetocardiography. Pacing Clin Electrophysiol 2000; 23 (8) 1305-1307
- 44 Cuneo BF, Zhao H, Strasburger JF, Ovadia M, Huhta JC, Wakai RT. Atrial and ventricular rate response and patterns of heart rate acceleration during maternal-fetal terbutaline treatment of fetal complete heart block. Am J Cardiol 2007; 100 (4) 661-665
- 45 Li Z, Strasburger JF, Cuneo BF, Gotteiner NL, Wakai RT. Giant fetal magnetocardiogram P waves in congenital atrioventricular block: a marker of cardiovascular compensation?. Circulation 2004; 110 (15) 2097-2101
- 46 van Leeuwen P, Hailer B, Bader W, Geissler J, Trowitzsch E, Grönemeyer DH. Magnetocardiography in the diagnosis of fetal arrhythmia. Br J Obstet Gynaecol 1999; 106 (11) 1200-1208
- 47 Wakai RT, Lengle JM, Leuthold AC. Transmission of electric and magnetic foetal cardiac signals in a case of ectopia cordis: the dominant role of the vernix. caseosa. Phys Med Biol 2000; 45 (7) 1989-1995
- 48 Das B, Cuneo BF, Ovadia M, Strasburger JF, Johnsrude C, Wakai RT. Magnetocardiography-guided management of an unusual case of isoimmune complete atrioventricular block complicated by ventricular tachycardia. Fetal Diagn Ther 2008; 24 (3) 282-285
- 49 Wakai RT, Strasburger JF, Li Z, Deal BJ, Gotteiner NL. Magnetocardiographic rhythm patterns at initiation and termination of fetal supraventricular tachycardia. Circulation 2003; 107 (2) 307-312
- 50 Peters C, Wacker-Gussmann A, Strasburger JF , et al. Electrophysiologic features of fetal ventricular aneurysms and diverticula. Cardiol Young 2013; 23 (Suppl. 01) S73
- 51 Wacker-Gussmann A, Strasburger JF, Cuneo B, Wiggins D, Gotteiner N, Wakai RT. Fetal arrhythmias associated with cardiac rhabdomyomas. Heart Rhythm 2013; 11 (4) 677-683
- 52 Crotti L, Tester DJ, White WM , et al. Long QT syndrome-associated mutations in intrauterine fetal death. JAMA 2013; 309 (14) 1473-1482
- 53 Eliasson H, Sonesson SE, Sharland G , et al; Fetal Working Group of the European Association of Pediatric Cardiology. Isolated atrioventricular block in the fetus: a retrospective, multinational, multicenter study of 175 patients. Circulation 2011; 124 (18) 1919-1926
- 54 Cuneo BF, Strasburger JF, Wakai RT, Ovadia M. Conduction system disease in fetuses evaluated for irregular cardiac rhythm. Fetal Diagn Ther 2006; 21 (3) 307-313
- 55 Mitchell JL, Cuneo BF, Etheridge SP, Horigome H, Weng HY, Benson DW. Fetal heart rate predictors of long QT syndrome. Circulation 2012; 126 (23) 2688-2695
- 56 Collazos JC, Acherman RJ, Law IH, Wilkes P, Restrepo H, Evans WN. Sustained fetal bradycardia with 1:1 atrioventricular conduction and long QT syndrome. Prenatal Diagnosis 2007; 27 (9) 879-881
- 57 Buyon JP, Clancy RM, Friedman DM. Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside. Nat Clin Pract Rheumatol 2009; 5 (3) 139-148
- 58 Izmirly PM, Saxena A, Kim MY , et al. Maternal and fetal factors associated with mortality and morbidity in a multi-racial/ethnic registry of anti-SSA/Ro-associated cardiac neonatal lupus. Circulation 2011; 124 (18) 1927-1935
- 59 Trucco SM, Jaeggi E, Cuneo B , et al. Use of intravenous gamma globulin and corticosteroids in the treatment of maternal autoantibody-mediated cardiomyopathy. J Am Coll Cardiol 2011; 57 (6) 715-723
- 60 Jaeggi ET, Silverman ED, Laskin C, Kingdom J, Golding F, Weber R. Prolongation of the atrioventricular conduction in fetuses exposed to maternal anti-Ro/SSA and anti-La/SSB antibodies did not predict progressive heart block. A prospective observational study on the effects of maternal antibodies on 165 fetuses. J Am Coll Cardiol 2011; 57 (13) 1487-1492
- 61 Baruteau AE, Fouchard S, Behaghel A , et al. Characteristics and long-term outcome of non-immune isolated atrioventricular block diagnosed in utero or early childhood: a multicentre study. Eur Heart J 2012; 33 (5) 622-629
- 62 Groves AM, Allan LD, Rosenthal E. Therapeutic trial of sympathomimetics in three cases of complete heart block in the fetus. Circulation 1995; 92 (12) 3394-3396
- 63 Jaeggi ET, Fouron JC, Silverman ED, Ryan G, Smallhorn J, Hornberger LK. Transplacental fetal treatment improves the outcome of prenatally diagnosed complete atrioventricular block without structural heart disease. Circulation 2004; 110 (12) 1542-1548
- 64 Ambrosi A, Salomonsson S, Eliasson H , et al. Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern. Ann Rheum Dis 2012; 71 (3) 334-340
- 65 Jaeggi ET, Carvalho JS, De Groot E , et al. Comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study. Circulation 2011; 124 (16) 1747-1754
- 66 Parilla BV, Strasburger JF, Socol ML. Fetal supraventricular tachycardia complicated by hydrops fetalis: a role for direct fetal intramuscular therapy. Am J Perinatol 1996; 13 (8) 483-486
- 67 van der Heijden LB, Oudijk MA, Manten GT, ter Heide H, Pistorius L, Freund MW. Sotalol as first-line treatment for fetal tachycardia and neonatal follow-up. Ultrasound Obstet Gynecol 2013; 42 (3) 285-293
- 68 Strasburger JF, Cuneo BF, Michon MM , et al. Amiodarone therapy for drug-refractory fetal tachycardia. Circulation 2004; 109 (3) 375-379
- 69 Jaeggi ET, Nii M. Fetal brady- and tachyarrhythmias: new and accepted diagnostic and treatment methods. Semin Fetal Neonatal Med 2005; 10 (6) 504-514
- 70 Krapp M, Kohl T, Simpson JM, Sharland GK, Katalinic A, Gembruch U. Review of diagnosis, treatment, and outcome of fetal atrial flutter compared with supraventricular tachycardia. Heart 2003; 89 (8) 913-917
- 71 Oudijk MA, Michon MM, Kleinman CS , et al. Sotalol in the treatment of fetal dysrhythmias. Circulation 2000; 101 (23) 2721-2726
- 72 Srinivasan S, Strasburger J. Overview of fetal arrhythmias. Curr Opin Pediatr 2008; 20 (5) 522-531
- 73 Naheed ZJ, Strasburger JF, Deal BJ, Benson Jr DW, Gidding SS. Fetal tachycardia: mechanisms and predictors of hydrops fetalis. J Am Coll Cardiol 1996; 27 (7) 1736-1740
- 74 Strasburger JF. Re: Sotalol as first-line treatment for fetal tachycardia and neonatal follow-up. L. B. van der Heijden, M. A. Oudijk, G. Manten, H. ter Heide, L. Pistorius and M. W. Freund. Ultrasound Obstet Gynecol 2013; 42: 285-293. Ultrasound Obstet Gynecol 2013; 42 (3) 254-255
- 75 Collins KK, Van Hare GF, Kertesz NJ , et al. Pediatric nonpost-operative junctional ectopic tachycardia medical management and interventional therapies. J Am Coll Cardiol 2009; 53 (8) 690-697
- 76 Horigome H, Nagashima M, Sumitomo N , et al. Clinical characteristics and genetic background of congenital long-QT syndrome diagnosed in fetal, neonatal, and infantile life: a nationwide questionnaire survey in Japan. Circ Arrhythm Electrophysiol 2010; 3 (1) 10-17
- 77 Simpson JM, Maxwell D, Rosenthal E, Gill H. Fetal ventricular tachycardia secondary to long QT syndrome treated with maternal intravenous magnesium: case report and review of the literature. Ultrasound Obstet Gynecol 2009; 34 (4) 475-480
- 78 Kominis IK, Kornack TW, Allred JC, Romalis MV. A subfemtotesla multichannel atomic magnetometer. Nature 2003; 422 (6932) 596-599
- 79 Shah VK, Wakai RT. A compact, high performance atomic magnetometer for biomedical applications. Phys Med Biol 2013; 58 (22) 8153-8161
- 80 Wyllie R, Kauer M, Smetana GS, Wakai RT, Walker TG. Magnetocardiography with a modular spin-exchange relaxation-free atomic magnetometer array. Phys Med Biol 2012; 57 (9) 2619-2632