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DOI: 10.1055/s-0034-1371711
Postnatal Respiratory Compliance among Premature Ventilated Neonates Associated with Variable Timing and Dosing of Antenatal Steroids
Publication History
31 December 2013
13 January 2014
Publication Date:
04 April 2014 (online)
![](https://www.thieme-connect.de/media/ajp/201412/lookinside/thumbnails/10.1055-s-0034-1371711-1.jpg)
Abstract
Background Antenatal steroids (ANSs) improve the respiratory compliance of premature infants. Many premature neonates are born before the administration of a complete course of ANS.
Objective The objective of this study was to evaluate the respiratory system compliance (Crs) of premature (≤ 32 weeks gestation), intubated neonates in relation to the dose, and timing of ANS administration.
Study Design Neonates (n = 61) were divided into four groups based on the dose and timing of ANS exposure: Group 1: no ANS; Group 2: partial course (one dose of betamethasone); Group 3: complete course (two doses of betamethasone administered within 2 weeks of delivery); and Group 4: remote course (two doses of betamethasone administered > 2 weeks before delivery). Crs was measured by single-breath occlusion technique.
Results Indexed respiratory compliance ± standard error of the mean (mL/cmH2O/kg) adjusted for gestational ages were 0.359 ± 0.074, 0.366 ± 0.080, 0.625 ± 0.038, and 0.505 ± 0.060 for Groups 1 to 4, respectively. The mean indexed Crs in complete ANS was significantly higher than that of no ANS (0.266 ± 0.085; p = 0.016) as well as partial ANS group (0.259 ± 0.086; p = 0.025).
Conclusions Crs after birth was significantly higher among premature intubated neonates born to mothers who received a complete course of ANS within 2 weeks, compared with no ANS or a partial course of ANS.
Note
This article was presented as a poster at: Chawla S, Natarajan G, Chen X, Gelmini M, and Lua J. Respiratory compliance in premature infants in relation to ANSs and postnatal surfactant. Pediatric Academic Society Meeting; May 2–5, 2009; Baltimore, MA. Abstract E-PAS2009:3860.177 and Chawla S, Natarajan G, and Lua J. Respiratory compliance in premature infants; effect of ANSs. 29th Annual Meeting of Society of Maternal Fetal Medicine Annual Conference; January 26–31, 2009; San Diego, CA.
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