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Drug Res (Stuttg) 2015; 65(1): 9-17
DOI: 10.1055/s-0034-1368721
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis and Characterization of Some Substituted 3, 4-dihydronaphthalene Derivatives through Different Enaminones as Potent Cytotoxic Agents

M. E. Haiba
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia
2   Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Center, Cairo, Egypt
,
E. S. Al-Abdullah
1   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia
,
M. M. Edrees
3   Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza, Egypt
4   Department of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia
,
N. M. Khalifa
2   Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Center, Cairo, Egypt
5   Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
› Author Affiliations
Further Information

Publication History

received 22 December 2013

accepted 03 February 2014

Publication Date:
12 August 2014 (online)

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Abstract

A new series of novel substituted 3,4-dihydronaphthalene incorporated to benzo[h]quinoline, benzo[g]indazole, thiazolidin-4-one, pyrazolo[3,4-d]thiazol and thiazolo[4,5-b]pyridine ring systems were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. Some of the tested compounds exhibited promising carcinoma growth inhibition. The detailed synthesis, spectroscopic data and biological activities of the tested compounds were reported.

Key words

3, 4-dihydronaphthalene - enaminone - anticancer agents
 

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