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Planta Med 2014; 80(07): 604-608
DOI: 10.1055/s-0034-1368427
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

α-Glucosidase Inhibitory Activities of Isoflavanones, Isoflavones, and Pterocarpans from Mucuna pruriens

Tshewang Dendup
1   Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand
,
Vilailak Prachyawarakorn
2   Chulabhorn Research Institute, Bangkok, Thailand
,
Acharavadee Pansanit
2   Chulabhorn Research Institute, Bangkok, Thailand
,
Chulabhorn Mahidol
1   Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand
2   Chulabhorn Research Institute, Bangkok, Thailand
,
Somsak Ruchirawat
1   Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand
2   Chulabhorn Research Institute, Bangkok, Thailand
3   Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok, Thailand
,
Prasat Kittakoop
1   Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand
2   Chulabhorn Research Institute, Bangkok, Thailand
3   Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok, Thailand
› Author Affiliations
Further Information

Publication History

received 05 September 2013
revised 07 March 2014

accepted 20 March 2014

Publication Date:
29 April 2014 (online)

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Abstract

Three new isoflavanones (1–3) and thirteen known compounds (4–16) were isolated from the roots of Mucuna pruriens. The absolute configurations of isoflavanones 1–3 and parvisoflavanone (4), lespedeol C (5), and uncinanone C (6) were addressed by a circular dichroism technique. Isoflavanones, isoflavones, and pterocarpans of M. pruriens were found to be α-glucosidase inhibitors. Medicarpin (7) and parvisoflavone B (9) were potent α-glucosidase inhibitors (twofold less active than the standard drug acarbose). The production of bioactive metabolites in M. pruriens seems to be season-dependent.

Key words

Mucuna pruriens - Fabaceae - α-glucosidase inhibitor - isoflavanone - isoflavone - pterocarpan

Supporting Information

 

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