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DOI: 10.1055/s-0034-1368155
Depression und Fatigue bei chronischer Entzündung – Welchen Einfluss haben zahnärztliche Maßnahmen?
Publication History
Publication Date:
25 January 2014 (online)
In Abhängigkeit der individuellen Suszeptibilität kann die Fremdstoffbelastung aus Zahnersatzmaterialien Trigger für chronische Entzündungen setzen, die von Symptomen aus dem depressiven Formenkreis begleitet werden. Dabei spielen Sensibilisierungen ebenso wie immuntoxische Reaktionen auf die im Mund freigesetzten Metalle, Kunststoffe und Einweißzerfallsprodukte eine wichtige Rolle. Der Zusammenhang zwischen Depression, Fatigue und Entzündung ist auf die Wirkung inflammatorischer Zytokine und die Veränderung des Tryptophan-Serotonin-Stoffwechsels zurückzuführen. Die Identifizierung individuell relevanter Triggerfaktoren und deren Expositionsvermeidung ist daher gerade auch vor dem klinischen Hintergrund einer depressiven Symptomatik eine wichtige Aufgabe der ganzheitlichen Zahnmedizin.
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Literatur
- 1 Maes M et al. Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways. Neuro Endocrinol Lett 2011; 32: 7-24
- 2 Pall ML. Explaining unexplained illnesses: Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress disorders, gulf war syndrome and others. Informa Healthcare 2007;
- 3 Valentine-Thon et al. LTT-MELISA is clinically relevant for detecting and monitoring metal sensitivity. Neuroendocrinol Lett 2006; 27: 17-24
- 4 Gardner RM et al. Mercury exposure, serum antinuclear/antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study. Environ Res 2010; 110: 345-354
- 5 Anisman H, Merali Z. Cytokines, stress and depressive illness: brain-immune interactions. Ann Med 2003; 35: 2-11
- 6 Capuron L, Miller AH. Cytokines and psychopathology: lessons from interferon-alpha. Biol Psychiatry 2004; 56: 819-824
- 7 Bluthé RM et al. Synergy between tumor necrosis factor alpha and interleukin-1 in the induction of sickness behavior in mice. Psychoneuroendocrinol 1994; 19: 197-207
- 8 Schiepers OJ G et al. Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29: 201-217
- 9 Utsuyama M, Hirokawa K. Differential expression of various cytokine receptors in the brain after stimulation with LPS in young and old mice. Exp Gerontol 2002; 37: 411-420
- 10 Müller N, Schwarz MJ. The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol Psychiatry 2007; 12: 988-1000
- 11 Coppen A. The biochemistry of affective disorders. Br J Psychiatry 1967; 113: 1237-1264
- 12 Merens et al. The effects of eperimentally lowered serotonin function on emotional information processing and memory in remitted depressive patients. J Psychopharmacol 2008; 22: 653-662
- 13 Schröcksnadel K et al. Monitoring tryptophan metabolism in chronic immune activation. Clin Chim Acta 2006; 364: 82-90
- 14 Miura H et al. A link between stress and depression: Shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Stress 2008; 11: 198-209
- 15 Myint AM et al. Kynurenine pathway in major depression: evidence of impaired neuroprotection. J Affect Disord 2007; 98: 143-151
- 16 Turner EH et al. Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacol Ther 2006; 109: 325-338
- 17 Müller N. COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence. Curr Opin Investig Drugs 2010; 11: 31-42
- 18 Raitala A et al. Association of interferon-gamma +874(T/A) single nucleotide polymorphism with the rate of tryptophan catabolism in healthy individuals. Scand J Immunol 2005; 61: 387-390
- 19 Wojcik DP et al. Mercury toxicity presenting as chronic fatigue, memory impairment and depression: diagnosis, treatment, susceptibility, and outcomes in a New Zealand general practice setting (1994–2006). Neuroendocrinol Lett 2006; 27: 415-423
- 20 Breivik et al. Glucocorticoid receptor antagonist RU 486 treatment reduces periodontitis in Fischer 344 rats. J Period Res 2000; 35: 285-290
- 21 Reece AS. An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey. Br Dent J 2008; 205