Download PDF
manuelletherapie 2013; 17(04): 153-161
DOI: 10.1055/s-0033-1356787
Schwerpunkt Schmerz
Einführung
Georg Thieme Verlag KG Stuttgart · New York

Update: Physiologie und Psychologie des Schmerzes

Jörg Trojan
1   Universität Koblenz-Landau, Fachbereich Psychologie, Fortstraße 7, 76829 Landau
,
Martin Diers
1   Zentralinstitut für Seelische Gesundheit, Institut für Neuropsychologie und Klinische Psychologie, Universität Heidelberg, Fakultät für Medizin Mannheim, J5, 68159 Mannheim
› Author Affiliations
Further Information

Publication History

Publication Date:
19 September 2013 (online)

    Permissions and Reprints

Zusammenfassung

DEN EINGEBILDETEN SCHMERZ gibt es nicht. Chronischer Schmerz ist das Ergebnis eines Lernprozesses. Patienten lernen den Schmerz und können ihn grundsätzlich auch wieder verlernen. Letzteres ist aber deutlich schwieriger. Den aktuellen Stand der Forschung lesen Sie hier.

 

  • Literatur

  • 1 Bair MJ, Robinson RL, Katon W et al. Depression and pain comorbidity: a literature review. Arch Intern Med 2003; 163: 2433-2445
    CrossrefPubMedGoogle Scholar
  • 2 Baliki MN, Geha PY, Apkarian AV. Parsing pain perception between nociceptive representation and magnitude estimation. J Neurophysiol 2009; 101: 875-887
    PubMedGoogle Scholar
  • 3 Baumgärtner U, Iannetti GD, Zambreanu L et al. Multiple somatotopic representations of heat and mechanical pain in the operculo-insular cortex: A high-resolution fMRI study. J Neurophysiol 2010; 104: 2863-2872
    CrossrefPubMedGoogle Scholar
  • 4 Baumgärtner U. Nozizeptives System. Schmerz 2010; 24: 105-113
    CrossrefPubMedGoogle Scholar
  • 5 Brooks JCW, Nurmikko TJ, Bimson WE et al. fMRI of thermal pain: Effects of stimulus laterality and attention. NeuroImage 2002; 15: 293-301
    CrossrefPubMedGoogle Scholar
  • 6 Brooks JCW, Zambreanu L, Godinez A et al. Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging. NeuroImage 2005; 27: 201-209
    CrossrefPubMedGoogle Scholar
  • 7 Craig AD. How do you feel?. Interoception: the sense of the physiological condition of the body Nat Rev Neurosci 2002; 3: 655-666
    CrossrefPubMedGoogle Scholar
  • 8 Craig AD. How do you feel—now?. The anterior insula and human awareness Nat Rev Neurosci 2009; 10: 59-70
    CrossrefPubMedGoogle Scholar
  • 9 Davis KD, Taylor SJ, Crawley AP et al. Functional MRI of pain- and attention-related activations in the human cingulate cortex. J Neurophysiol 1997; 77: 3370-3380
    PubMedGoogle Scholar
  • 10 Derbyshire SW, Jones AK, Gyulai F et al. Pain processing during three levels of noxious stimulation produces differential patterns of central activity. Pain 1997; 73: 431-445
    CrossrefPubMedGoogle Scholar
  • 11 Diers M, Yilmaz P, Rance M et al. Treatment-related changes in brain activation in patients with fibromyalgia syndrome. Exp Brain Res 2012; 218: 619-628
    CrossrefPubMedGoogle Scholar
  • 12 Fordyce WE. Behavioral methods for chronic pain and illness. Saint Louis: Mosby; 1976
    Google Scholar
  • 13 Hees JV, Gybels JC. Nociceptor activity in human nerve during painful and non painful skin stimulation. J Neurol Neurosurg Psychiatry 1981; 44: 600-607
    CrossrefPubMedGoogle Scholar
  • 14 Hsieh JC, Stone-Elander S, Ingvar M. Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study. Neurosci Lett 1999; 262: 61-64
    CrossrefPubMedGoogle Scholar
  • 15 International Association for the Study of Pain (IASP). http://www.iasp-pain.org/Content/NavigationMenu/GeneralResourceLinks/PainDefinitions Übersetzung der Autoren Stand: 6.6.2013
    PubMed
  • 16 International Association for the Study of Pain (IASP). http://www.iasp-pain.org/Content/NavigationMenu/Publications/FreeBooks/Classification_of_Chronic_Pain Stand: 6.6.2013
    PubMed
  • 17 Jensen KB, Kosek E, Wicksell R et al. Cognitive Behavioral Therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgeia. PAIN 2012; 153: 1495-1503
    CrossrefPubMedGoogle Scholar
  • 18 Kong J, White NS, Kwong KK et al. Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity. Human Brain Mapping 2006; 27: 715-721
    CrossrefPubMedGoogle Scholar
  • 19 Kwan CL, Crawley AP, Mikulis DJ et al. An fMRI study of the anterior cingulate cortex and surrounding medial wall activations evoked by noxious cutaneous heat and cold stimuli. Pain 2000; 85: 359-374
    CrossrefPubMedGoogle Scholar
  • 20 Legrain V, Iannetti GD, Plaghki L et al. The pain matrix reloaded: A salience detection system for the body. Prog Neurobiol 2011; 93: 111-124
    CrossrefPubMedGoogle Scholar
  • 21 Lethem J, Slade PD, Troup JDG et al. Outline of a fear-avoidance model of exaggerated pain perception—I.. Behav Res Ther 1983; 21: 401-408
    CrossrefPubMedGoogle Scholar
  • 22 Melzack R, Casey KL, Kenshalo DR. Sensory, Motivational, and Central Control Determinants of Pain. In: Kenshalo DR, Hrsg. The Skin Senses. Springfield, IL: Thomas; 1968
    Google Scholar
  • 23 Millecamps M, Centeno MV, Berra HH et al. d-Cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry. Pain 2007; 132: 108-123
    CrossrefPubMedGoogle Scholar
  • 24 Myers KM, Davis M. Mechanisms of fear extinction. Mol Psychiatry 2006; 12: 120-150
    PubMedGoogle Scholar
  • 25 Paquette V, Lévesque J, Mensour B et al. “Change the mind and you change the brain”: effects of cognitive-behavioral therapy on the neural correlates of spider phobia. NeuroImage 2003; 18: 401-409
    CrossrefPubMedGoogle Scholar
  • 26 Ploghaus A, Tracey I, Gati JS et al. Dissociating Pain from Its Anticipation in the Human Brain. Science 1999; 284: 1979-1981
    CrossrefPubMedGoogle Scholar
  • 27 Raja SN, Meyer RA, Campbell JN. Hyperalgesia and sensitization of primary afferent fibres. In: Pain Syndromes in Neurology. London: Butterworths; 1990
    Google Scholar
  • 28 Ressler KJ, Rothbaum BO, Tannenbaum L et al. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry 2004; 61: 1136-1144
    CrossrefPubMedGoogle Scholar
  • 29 Schaible HG. Nozizeption und Schmerz. In: Schmidt RF, Lang F, Heckmann M, Hrsg. Physiologie des Menschen. Berlin, Heidelberg: Springer; 2011
    CrossrefGoogle Scholar
  • 30 Schmidt RF, Lang F, Heckmann M Hrsg. Physiologie des Menschen. 31. Aufl.. Heidelberg: Springer; 2011
    CrossrefGoogle Scholar
  • 31 Schmidt RF, Schmelz M, Forster C et al. Novel classes of responsive and unresponsive C nociceptors in human skin. J Neurosci 1995; 15: 333-341
    PubMedGoogle Scholar
  • 32 Schünke M, Schulte E, Schumacher U. Prometheus. LernAtlas der Anatomie. Kopf, Hals und Neuroanatomie. Illustrationen von M. Voll und K. Wesker 3. Aufl. Stuttgart: Thieme; 2012
    Google Scholar
  • 33 Thieme K, Flor H, Turk DC. Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments. Arthritis Res Ther 2006; 8: R121-R121
    CrossrefPubMedGoogle Scholar
  • 34 Thieme K, Gromnica-Ihle E, Flor H. Operant behavioral treatment of fibromyalgia: A controlled study. Arthritis Care Res 2003; 49: 314-320
    CrossrefPubMedGoogle Scholar
  • 35 Thieme K, Turk DC, Flor H. Comorbid depression and anxiety in fibromyalgia syndrome: Relationship to somatic and psychosocial variables. Psychosom Med 2004; 66: 837-844
    CrossrefPubMedGoogle Scholar
  • 36 Treede RD, Apkarian AV, Bromm B et al. Cortical representation of pain: functional characterization of nociceptive areas near the lateral sulcus. Pain 2000; 87: 113-119
    CrossrefPubMedGoogle Scholar
  • 37 Turk DC, Okifuji A. Psychological factors in chronic pain: evolution and revolution. J Consult Clin Psychol 2002; 70: 678-690
    PubMedGoogle Scholar
  • 38 Turk DC. Pain and behavioral medicine: a cognitive-behavioral perspective. New York: Guilford Press; 1983
    Google Scholar
  • 39 Valet M, Sprenger T, Boecker H et al. Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain—an fMRI analysis. Pain 2004; 109: 399-408
    CrossrefPubMedGoogle Scholar
  • 40 Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 2005; 6: 533-544
    PubMedGoogle Scholar
  • 41 Wiech K, Kalisch R, Weiskopf N et al. Anterolateral prefrontal cortex mediates the analgesic effect of expected and perceived control over pain. J Neurosci 2006; 26: 11501-11509
    CrossrefPubMedGoogle Scholar
  • 42 Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science 2000; 288: 1765-1769
    CrossrefPubMedGoogle Scholar