Semin Thromb Hemost 2013; 39(07): 794-802
DOI: 10.1055/s-0033-1354424
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Emerging Issues on Comprehensive Hemophilia Care: Preventing, Identifying, and Monitoring Age-Related Comorbidities

Antonio Coppola
1   Department of Clinical Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University Hospital, Naples, Italy
,
Cristina Santoro
2   Division of Hematology, Department of Cellular Biotechnology and Hematology, Sapienza University, Rome, Italy
,
Massimo Franchini
3   Department of Immunohematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy
,
Caterina Mannucci
4   Bayer Italia, Milan, Italy
,
Selene Mogavero
5   Primula Multimedia, Pisa, Italy
,
Angelo Claudio Molinari
6   Department of Experimental and Laboratory Medicine, Regional Reference Center for Hemorrhagic Diseases, Giannina Gaslini Institute, Genoa, Italy
,
Piercarla Schinco
7   Regional Reference Center for Thrombotic and Haemorrhagic Disorders, Hemophilia Center, University Hospital S. Giovanni Battista, Torino, Italy
,
Annarita Tagliaferri
8   Department of Medicine, Regional Reference Center for Inherited Bleeding Disorders, University Hospital of Parma, Parma, Italy
,
Rita Carlotta Santoro
9   Department of Oncology and Hematology, Hemophilia Center, Hemostasis and Thrombosis Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
08 September 2013 (online)

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Abstract

Life expectancy for persons with hemophilia (PWH) has considerably increased in the last decades as a direct result of the availability of modern therapies to control the clotting defect. Because their life expectancy now matches that of the general population, PWH are experiencing age-related comorbidities, such as, cardiovascular diseases, metabolic syndrome, renal diseases, sexuality issues, malignancies, and neurologic problems, that until recently have been rarely seen in this group of patients. In this article, we present a summary of the current knowledge on the aging PWH along with the clinical approaches that may be integrated into the routine comprehensive care of these patients for preventing, diagnosing, and monitoring age-related comorbidities. In general, patients with and without hemophilia should receive similar care, with close collaboration between the physician treating PWH and the specialty expert treating the comorbid disease.

Note

All the authors took part in drafting this manuscript and approved its final version.