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DOI: 10.1055/s-0033-1354402
Resistance Exercise Training does not Affect Plasma Irisin Levels of Hemodialysis Patients
Publikationsverlauf
received 22. April 2013
accepted 12. August 2013
Publikationsdatum:
06. September 2013 (online)
![](https://www.thieme-connect.de/media/hmr/201312/lookinside/thumbnails/10.1055-s-0033-1354402-1.jpg)
Abstract
Irisin, a hormone secreted by myocytes induced in exercise, acts as a muscle-derived energy-expenditure signal that binds to undetermined receptors on the white adipose tissue surface, stimulating its browning and uncoupling protein 1 (UCP1) expression. The purpose of this study was to assess the effect of an intradialytic resistance exercise training program (RETP) on plasma irisin levels of hemodialysis (HD) patients and compare the baseline plasma irisin levels of HD patients to healthy subjects. This longitudinal study enrolled 26 patients undergoing HD (50% men, 44.8±14.1 years, body mass index (BMI) 23.5±3.9 kg/m2). The healthy subjects group consisted of 11 women and 7 men with mean age of 50.9±6.6 years and BMI, 24.2±2.7 kg/m2. Anthropometric and biochemistry parameters (Irisin by Enzyme-Linked Immunosorbent Assay) were measured at the baseline and after 6 months of RETP (in both lower limbs). There was no difference regarding gender, age, and BMI between HD patients and healthy subjects. Plasma irisin levels in HD patients were lower than in healthy subjects (71.0±41.6 vs. 101.3±12.5 ng/ml, p<0.05). Although the muscle mass increased in consequence of exercise [evaluated by arm muscle area from 27.9 (24.1) to 33.1 (19.0) cm2], plasma irisin did not differ significantly after exercises (71.0±41.6 vs. 73.3±36.0 ng/ml). HD patients seem to have lower plasma irisin when compared to healthy subjects. Moreover, a resistance exercise training program was unable to augment plasma irisin despite increasing muscle mass.
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References
- 1 Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 2012; 8: 457-465
- 2 Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481: 463-468
- 3 Finck BN, Kelly DP. PGC-1 coactivators: inducible regulators oaf energy metabolism in health and disease. J Clin Invest 2006; 116: 615-622
- 4 Handschin C, Spiegelman BM. The role of exercise and PGC1alpha in inflammation and chronic disease. Nature 2008; 454: 463-469
- 5 Kelly DP. Irisin, Light my Fire. Science 2012; 336: 42-43
- 6 Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE. Mantzoros. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012; 61: 1725-1738
- 7 Cheema B, Abas H, Smith B, O’Sullivan A, Chan M, Patwardhan A, Kelly J, Gillin A, pang G, Lyoyd B, Singh MF. Progressive Exercise for Anabolism in Kidney Disease (PEAK): A Randomized, Controlled Trial of Resistance Training during Hemodialysis. Am J Kidney Dis 2007; 50: 574-584
- 8 Chen JL, Godfrey S, Ng TT, Moorthi R, Liangos O, Ruthazer R, Jaber BL, Levey AS, Castaneda-Sceppa C. Effect of intra-dialytic, low-intensity strength training on functional capacity in adult haemodialysis patients: a randomized pilot Trial. Nephrol Dial Transplant 2010; 25: 1936-1943
- 9 Wen MS, Wang CY, Lin SL, Hung KC. Decrease in irisin in patients with chronic kidney disease. PLoS One 2013; 8: e64025
- 10 Simão R, Poly MA, Lemos A. Prescrição de exercícios através do teste de T1 RM em homens treinados. Fit Perf J 2004; 3: 47-51
- 11 Sargent J, Gotch F. Principles and biophysics of dialysis. In: Drukker W, Parsons F, Maher J. (eds.) Replacement of Renal Function by Dialysis. The Hague: Martinues Nijhoff; 1985: 15-63
- 12 World Health Organization . Obesity: preventing and managing the global epidemic: report of a WHO Consultation. Geneva, Switzerland: World Health Organization; 2000. WHO Technical Report Series 894
- 13 Heymsfield SB, McManus C, Smith J, Stevens V, Nixon DW. Anthropometric measurement of muscle mass: revised equations for calculating bone-free arm muscle area. Am J Clin Nutr 1982; 36: 680-690
- 14 Durnin JV, Womersley J. Body fat assessed from total body density and its estimation from skin-fold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 1974; 32: 77-97
- 15 Siri WE. Body composition from fluid space and density. In: Brozek J, Hanschel A. eds. Techniques for measuring body composition. Washington, D.C: National Academy of Science; 1961: 223-224
- 16 Timmons JA, Baar K, Davidsen PK, Atherton PJ. Is irisin a human exercise gene?. Nature 2012; 488 (7413) E9-E10 [discussion E-1]
- 17 Stengel A, Hofmann T, Stengel MG. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index. Peptides 2013; 39: 125-130
- 18 Choi YK, Kim MK, Bae KH, Seo HA, Jeong JY, Lee WK, Kim JG, Lee IK, Park KG. Serum irisin levels in new-onset type 2 diabetes. Diabetes Res Clin Pract 2013; 100: 96-101
- 19 Liu JJ, Wong MD, Toy WC, Tan CS, Liu S, Ng XW, Tavintharan S, Sum CF, Lim SC. Lower circulating irisin is associated with type 2 diabetes mellitus. J Diabetes Complications 2013; 27: 365-369
- 20 Kerr PG, Strauss BJG, Atkins RC. Assessment of the nutritional state of dialysis patients. Blood Purif 1996; 14: 121-126
- 21 Kamimura MA, Avesani CM, Cenderoglo M, Canziani ME, Draibe SA, Cuppari L. Comparison of skinfold thicknesses and bioelectrical impedance analysis with dual-energy x-ray absorptiometry for the assessment of body fat in patients on long-term hemodialysis therapy. Nephrol Dial Transplant 2003; 18: 101-105