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DOI: 10.1055/s-0033-1352182
New neolignans from leaves of Miliusa mollis
Miliusa mollis Pierre (Annonaceae) is a shrub found in the northern and central regions of Thailand where it is locally known as Ching-chap [1]. Recently, the presence of neolignans, aporphine alkaloids and phenolic glycoside in the twigs of M. mollis has been reported [2]. In this study, we report the isolation of six new neolignans from the leaves of this plant including miliumollin (1), 4'-O-methylmiliumollin (2), 3'-methoxymiliumollin (3), 7-methoxymiliumollin (4), miliumollinone (5) and miliusamollin (6), and a known compound named decurrenal (7). Their structures were elucidated through analysis of their spectroscopic data. Four neolignans (1, 3, 5 and 7) exhibited weak cytotoxic against KB, MCF7 and NCI-H187 cells, but only 5 showed weak inhibitory effects against herpes simplex virus types 1 and 2 (HSV1 and HSV-2).
Acknowledgements: The Thailand Research Found in the form of a Royal Golden Jubilee Ph.D. scholarship (PHD/0261/2549), The French Embassy in Thailand for an RGJ-matching grant, Chulalongkorn University Graduate Scholaship in Commemoration of HM King Bhumibol Adulyadej's 72nd Anniversary
References:
[1] Smitinand, T. (2001) Thai Plant Names, revised Ed. Prachachon Co. Ltd. Bangkok, Thailand.
[2] Sawasdee, K. et al. (2010) Molecules 15: 639 – 648.