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Horm Metab Res 2013; 45(13): 960-966
DOI: 10.1055/s-0033-1351322
Review
© Georg Thieme Verlag KG Stuttgart · New York

The Brain: A New Organ for the Metabolic Actions of SIRT1

O. Al Massadi   *
1   Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), San Francisco s/n, Santiago de Compostela (A Coruña), Spain
2   University of Santiago de Compostela Santiago de Compostela, Santiago de Compostela, Spain
,
M. Quiñones   *
1   Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), San Francisco s/n, Santiago de Compostela (A Coruña), Spain
2   University of Santiago de Compostela Santiago de Compostela, Santiago de Compostela, Spain
,
P. Lear
1   Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), San Francisco s/n, Santiago de Compostela (A Coruña), Spain
2   University of Santiago de Compostela Santiago de Compostela, Santiago de Compostela, Spain
,
C. Dieguez
1   Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), San Francisco s/n, Santiago de Compostela (A Coruña), Spain
2   University of Santiago de Compostela Santiago de Compostela, Santiago de Compostela, Spain
,
R. Nogueiras
1   Department of Physiology, School of Medicine-CIMUS, Instituto de Investigacion Sanitaria (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), San Francisco s/n, Santiago de Compostela (A Coruña), Spain
2   University of Santiago de Compostela Santiago de Compostela, Santiago de Compostela, Spain
› Author Affiliations
Further Information

Publication History

received 03 May 2013

accepted 09 July 2013

Publication Date:
15 August 2013 (online)

Also available at
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Abstract

The sirtuins are a family of highly conserved nicotine adenine dinucleotide (NAD+)-dependent deacetylases that act as cellular sensors to detect energy availability and regulate metabolic processes. Sirtuin 1 (SIRT1) is one of the family members that is activated in response to caloric restriction, acting on multiple targets in a wide range of tissues. Recent studies have shown that SIRT1 controls glucose and lipid metabolism in both liver and muscle, promotes fat mobilization, stimulates remodeling of white to brown fat, controls insulin secretion in the pancreas, and senses nutrient availability in the hypothalamus. SIRT1 is located in several areas of the brain and its central metabolic actions have attracted much attention in the last decade. In this short review, we summarize the main actions and molecular pathways triggered by SIRT1 that control feeding behavior, energy expenditure, glucose metabolism, and insulin sensitivity, with an emphasis on the emerging role of SIRT1 in the brain.

Key words

insulin sensitivity - adipose tissue - impaired glucose tolerance - obesity

* These authors contributed equally to the ­manuscript.


 

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