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DOI: 10.1055/s-0033-1351025
Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities
Publikationsverlauf
received 08. Februar 2013
revised 24. Juli 2013
accepted 05. Oktober 2013
Publikationsdatum:
19. Dezember 2013 (online)
![](https://www.thieme-connect.de/media/plantamedica/201318/lookinside/thumbnails/10.1055-s-0033-1351025-1.jpg)
Abstract
From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.
Key words
Godmania aesculifolia - Bignoniaceae - lapachol - chavicol diglycoside - Trichophyton spp. - Microsporum spp. - Aspergillus spp. - Candida - Cryptococcus neoformans-
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