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DOI: 10.1055/s-0033-1350648
Diterpenes and Phenylpropanoids from Clerodendrum splendens
Publikationsverlauf
received 05. Mai 2013
revised 12. Juni 2013
accepted 25. Juni 2013
Publikationsdatum:
08. August 2013 (online)
![](https://www.thieme-connect.de/media/plantamedica/201314/lookinside/thumbnails/10.1055-s-0033-1350648-1.jpg)
Abstract
Four new clerodane diterpenes (1–4) and one new phenylpropanoid (5) have been isolated from Clerodendrum splendens aerial parts, together with nine known compounds. Their structures were determined by spectroscopic and spectrometric analysis and chemical methods. The absolute configuration of the 15,16-diol moiety in 4 was determined by Snatzkeʼs method. Antiproliferative activity of diterpenes in HeLa cells was also evaluated. The IC50 values were 98 ± 11 µM for 3 and 101 ± 8 µM for 1, respectively.
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