Clin Colon Rectal Surg 2013; 26(02): 106-111
DOI: 10.1055/s-0033-1348049
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Prevention and Management of Nonhealing Perineal Wounds

Allen Kamrava
1   LA Colon and Rectal Surgical Associates, Beverly Hills, California
,
Najjia N. Mahmoud
2   Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
› Author Affiliations
Further Information

Publication History

Publication Date:
27 June 2013 (online)

Abstract

Complex perineal wounds are at risk for nonhealing. High-risk procedures include proctectomy for Crohn disease, anal cancer and radiated distal rectal cancers. A basic understanding of both patient and procedural risk factors is helpful in planning and executing operative procedures for these conditions and to minimize associated wound complications. Diabetes, obesity, and malnutrition may contribute to wound breakdown and failure to heal. Delaying operative intervention, adding nutritional supplementation, and employing intestinal diversion as well as myocutaneous flaps may help optimize conditions for wound healing.

 
  • References

  • 1 Zorcolo L, Restivo A, Capra F, Fantola G, Marongiu L, Casula G. Does long-course radiotherapy influence postoperative perineal morbidity after abdominoperineal resection of the rectum for cancer?. Colorectal Dis 2011; 13 (12) 1407-1412
  • 2 Bullard KM, Trudel JL, Baxter NN, Rothenberger DA. Primary perineal wound closure after preoperative radiotherapy and abdominoperineal resection has a high incidence of wound failure. Dis Colon Rectum 2005; 48 (3) 438-443
  • 3 El-Gazzaz G, Kiran RP, Lavery I. Wound complications in rectal cancer patients undergoing primary closure of the perineal wound after abdominoperineal resection. Dis Colon Rectum 2009; 52 (12) 1962-1966
  • 4 Matsuda K, Hotta T, Takifuji K , et al. Long-term comorbidity of diabetes mellitus is a risk factor for perineal wound complications after an abdominoperineal resection. Langenbecks Arch Surg 2009; 394 (1) 65-70
  • 5 Turner II, Russell GB, Blackstock AW, Levine EA. Impact of neoadjuvant therapy on postoperative complications in patients undergoing resection for rectal adenocarcinoma. Am Surg 2004; 70 (12) 1045-1049
  • 6 Miles W. A method of performing APR for adenocarcinoma of the low rectum. Lancet 1908; 2: 1912
  • 7 Showalter S, Kelz RR, Mahmoud NN. Effect of technique on postoperative perineal wound infections in abdominoperineal resection. Am J Surg 2012; . Accepted
  • 8 Kapoor V, Cole J, Isik FF, Sinanan M, Flum D. Does the use of a flap during abdominoperineal resection decrease pelvic wound morbidity?. Am Surg 2005; 71 (2) 117-122
  • 9 Nisar PJ, Scott HJ. Myocutaneous flap reconstruction of the pelvis after abdominoperineal excision. Colorectal Dis 2009; 11 (8) 806-816
  • 10 Ferenschild FT, Vermaas M, Hofer SO, Verhoef C, Eggermont AM, de Wilt JH. Salvage abdominoperineal resection and perineal wound healing in local recurrent or persistent anal cancer. World J Surg 2005; 29 (11) 1452-1457
  • 11 Tei TM, Stolzenburg T, Buntzen S, Laurberg S, Kjeldsen H. Use of transpelvic rectus abdominis musculocutaneous flap for anal cancer salvage surgery. Br J Surg 2003; 90 (5) 575-580
  • 12 Shibata D, Hyland W, Busse P , et al. Immediate reconstruction of the perineal wound with gracilis muscle flaps following abdominoperineal resection and intraoperative radiation therapy for recurrent carcinoma of the rectum. Ann Surg Oncol 1999; 6 (1) 33-37
  • 13 Anderin C, Martling A, Lagergren J, Ljung A, Holm T. Short-term outcome after gluteus maximus myocutaneous flap reconstruction of the pelvic floor following extra-levator abdominoperineal excision of the rectum. Colorectal Dis 2012; 14 (9) 1060-1064
  • 14 Baird WL, Hester TR, Nahai F, Bostwick III J. Management of perineal wounds following abdominoperineal resection with inferior gluteal flaps. Arch Surg 1990; 125 (11) 1486-1489
  • 15 Tompkins RG, Warshaw AL. Improved management of the perineal wound after proctectomy. Ann Surg 1985; 202 (6) 760-765
  • 16 Elliot MS, Todd IP. Primary suture of the perineal wound using constant suction and irrigation, following rectal excision for inflammatory bowel disease. Ann R Coll Surg Engl 1985; 67 (1) 6-7
  • 17 McLeod R, Cohen Z, Langer B, Taylor B. Primary perineal wound closure following excision of the rectum. Can J Surg 1983; 26 (2) 122-124
  • 18 Marks CG, Ritchie JK, Todd IP, Wadsworth J. Primary suture of the perineal wound following rectal excision for inflammatory bowel disease. Br J Surg 1978; 65 (8) 560-564
  • 19 Warshaw AL, Ottinger LW, Bartlett MK. Primary perineal closure after proctocolectomy for inflammatory bowel disease. Prevention of the persistent perineal sinus. Am J Surg 1977; 133 (4) 414-419
  • 20 Delalande JP, Hay JM, Fingerhut A, Kohlmann G, Paquet JC. French Association for Surgical Research. Perineal wound management after abdominoperineal rectal excision for carcinoma with unsatisfactory hemostasis or gross septic contamination: primary closure vs. packing. A multicenter, controlled trial. Dis Colon Rectum 1994; 37 (9) 890-896
  • 21 Keighley MR, Allan RN. Current status and influence of operation on perianal Crohn's disease. Int J Colorectal Dis 1986; 1 (2) 104-107
  • 22 De Dombal FT, Burton I, Goligher JC. The early and late results of surgical treatment for Crohn's disease. Br J Surg 1971; 58 (11) 805-816
  • 23 Ritchie JK. Ileostomy and excisional surgery for chronic inflammatory disease of the colon: a survey of one hospital region. Gut 1971; 12 (7) 528-540
  • 24 Yamamoto T, Bain IM, Allan RN, Keighley MRB. Persistent perineal sinus after proctocolectomy for Crohn's disease. Dis Colon Rectum 1999; 42 (1) 96-101
  • 25 Linares L, Moreira LF, Andrews H, Allan RN, Alexander-Williams J, Keighley MR. Natural history and treatment of anorectal strictures complicating Crohn's disease. Br J Surg 1988; 75 (7) 653-655
  • 26 Fields S, Rosainz L, Korelitz BI, Panagopoulos G, Schneider J. Rectal strictures in Crohn's disease and coexisting perirectal complications. Inflamm Bowel Dis 2008; 14 (1) 29-31
  • 27 Sousa Guerreiro C, Cravo M, Costa AR , et al. A comprehensive approach to evaluate nutritional status in Crohn's patients in the era of biologic therapy: a case-control study. Am J Gastroenterol 2007; 102 (11) 2551-2556
  • 28 Hwang C, Ross V, Mahadevan U. Micronutrient deficiencies in inflammatory bowel disease: from A to zinc. Inflamm Bowel Dis 2012; 18 (10) 1961-1981
  • 29 Sinno S, Lee DS, Khachemoune A. Vitamins and cutaneous wound healing. J Wound Care 2011; 20 (6) 287-293
  • 30 Anstead GM. Steroids, retinoids, and wound healing. Adv Wound Care 1998; 11 (6) 277-285
  • 31 Gendall KA, Raniga S, Kennedy R, Frizelle FA. The impact of obesity on outcome after major colorectal surgery. Dis Colon Rectum 2007; 50 (12) 2223-2237
  • 32 Nyström PO, Jonstam A, Höjer H, Ling L. Incisional infection after colorectal surgery in obese patients. Acta Chir Scand 1987; 153 (3) 225-227
  • 33 Benoist S, Panis Y, Alves A, Valleur P. Impact of obesity on surgical outcomes after colorectal resection. Am J Surg 2000; 179 (4) 275-281
  • 34 Duffy LC, Zielezny MA, Marshall JR , et al. Cigarette smoking and risk of clinical relapse in patients with Crohn's disease. Am J Prev Med 1990; 6 (3) 161-166
  • 35 Sutherland LR, Ramcharan S, Bryant H, Fick G. Effect of cigarette smoking on recurrence of Crohn's disease. Gastroenterology 1990; 98 (5 Pt 1) 1123-1128
  • 36 Cottone M, Rosselli M, Orlando A , et al. Smoking habits and recurrence in Crohn's disease. Gastroenterology 1994; 106 (3) 643-648
  • 37 Goertz O, Kapalschinski N, Skorzinski T , et al. [Wound healing complications in smokers, non-smokers and after abstinence from smoking]. Chirurg 2012; 83 (7) 652-656
  • 38 Sorensen LT, Karlsmark T, Gottrup F. Abstinence from smoking reduces incisional wound infection: a randomized controlled trial. Ann Surg 2003; 238 (1) 1-5
  • 39 Kasparek MS, Bruckmeier A, Beigel F , et al. Infliximab does not affect postoperative complication rates in Crohn's patients undergoing abdominal surgery. Inflamm Bowel Dis 2012; 18 (7) 1207-1213
  • 40 Colombel JF, Loftus Jr EV, Tremaine WJ , et al. Early postoperative complications are not increased in patients with Crohn's disease treated perioperatively with infliximab or immunosuppressive therapy. Am J Gastroenterol 2004; 99 (5) 878-883
  • 41 Kunitake H, Hodin R, Shellito PC, Sands BE, Korzenik J, Bordeianou L. Perioperative treatment with infliximab in patients with Crohn's disease and ulcerative colitis is not associated with an increased rate of postoperative complications. J Gastrointest Surg 2008; 12 (10) 1730-1736 , discussion 1736–1737
  • 42 Sarani B, Orkin BA. Squamous Cell CA arising in an unhealed wound in Crohn's disease. South Med J 1997; 90 (9) 940-942
  • 43 Buchman AL, Arment ME, Doty J. Development of squamous cell CA in chronic perineal sinus and wound in CD. AM J. Gastro 1991; 86: 1829-1832
  • 44 Ky A, Sohn N, Weinstein MA, Korelitz BI. Carcinoma arising in anorectal fistulas of Crohn's disease. Dis Colon Rectum 1998; 41 (8) 992-996
  • 45 Smith R, Hicks D, Tomljanovich PI, Lele SB, Rajput A, Dunn KB. Adenocarcinoma arising from chronic perianal Crohn's disease: case report and review of the literature. Am Surg 2008; 74 (1) 59-61
  • 46 Iesalnieks I, Gaertner WB, Glass H , et al. Fistula-associated anal adenocarcinoma in Crohn's disease. Inflamm Bowel Dis 2010; 16 (10) 1643-1648
  • 47 Wiatrek RL, Thomas JS, Papaconstantinou HT. Perineal wound complications after abdominoperineal resection. Clin Colon Rectal Surg 2008; 21 (1) 76-85
  • 48 Cresti S, Ouaïssi M, Sielezneff I , et al. Advantage of vacuum assisted closure on healing of wound associated with omentoplasty after abdominoperineal excision: a case report. World J Surg Oncol 2008; 6: 136
  • 49 Watts JM, de Dombal FT, Goligher JC. Long-term complications and prognosis following major surgery for ulcerative colitis. Br J Surg 1966; 53 (12) 1014-1023
  • 50 Ferrari BT, DenBesten L. The prevention and treatment of the persistent perineal sinus. World J Surg 1980; 4 (2) 167-172
  • 51 Menon A, Clark MA, Shatari T, Keh C, Keighley MR. Pedicled flaps in the treatment of nonhealing perineal wounds. Colorectal Dis 2005; 7 (5) 441-444
  • 52 Galandiuk S, Jorden J, Mahid S, McCafferty MH, Tobin G. The use of tissue flaps as an adjunct to pelvic surgery. Am J Surg 2005; 190 (2) 186-190
  • 53 Anthony JP, Mathes SJ. The recalcitrant perineal wound after rectal extirpation. Applications of muscle flap closure. Arch Surg 1990; 125 (10) 1371-1376 , discussion 1376–1377
  • 54 Hurst RD, Gottlieb LJ, Crucitti P, Melis M, Rubin M, Michelassi F. Primary closure of complicated perineal wounds with myocutaneous and fasciocutaneous flaps after proctectomy for Crohn's disease. Surgery 2001; 130 (4) 767-772 , discussion 772–773