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DOI: 10.1055/s-0033-1345128
Effects of Different Physical Exercises on Leptin Concentration in Obese Adolescents
Publikationsverlauf
accepted after revision 26. März 2013
Publikationsdatum:
18. Juli 2013 (online)
![](https://www.thieme-connect.de/media/sportsmed/201402/lookinside/thumbnails/10.1055-s-0033-1345128-1.jpg)
Abstract
In order to compare the effects of leisure physical activity (LPA), aerobic training (AT) and aerobic plus resistance training (AT+RT) as part of a 6-month interdisciplinary therapy in body composition, insulin resistance and leptin concentrations in obese adolescents, 72 volunteers (n=24 in each group) ages 15–19 years were evaluated. Delta (Δ) body mass (kg) and Δ BMI (kg/m2) was different between AT and LPA groups and in AT+RT group compared to both LPA and AT groups; Δ body fat mass (kg and %) was different only in AT+RT group compared to both LPA and AT; Δ body lean mass (%) was different only in AT+RT group; Δ body lean mass (kg) was negative only in AT and positive and different from AT in AT+RT group; ΔHOMA-IR did not differ among groups; Δ leptin (ng/ml) was negative and different from LPA for both AT and AT+RT groups. In conclusion, both AT and AT+RT promoted a reduction on leptin levels, however, the adolescents subjected to AT+RT presented better results in body composition than the AT group. These results highlight the importance of associating aerobic and resistance training with nutritional and psychological approaches in the treatment of obese adolescents.
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References
- 1 Arora S, Anabhuti AS. Role of neuropeptides in appetite regulation and obesity – a review. Neuropeptides 2006; 40: 375-401
- 2 Arrieta A, Russell LB. Effects of leisure and non-leisure physical activity on mortality in U.S. adults over two decades. Ann Epidemiol 2008; 18: 889-895
- 3 Barbeau P, Gutin B, Litaker MS, Ramsey LT, Cannady WE, Allison J, Lemmon CR, Owens S. Influence of physical training on plasma leptin in obese youths. Can J Appl Physiol 2003; 28: 382-396
- 4 Bell LM, Watts K, Siafarikas A, Thompson A, Ratnam N, Bulsara M, Finn J, O’Driscoll G, Green DJ, Jones TW, Davis EA. Exercise alone reduces insulin resistance in obese children independently of changes in body composition. J Clin Endocrinol Metab 2007; 92: 4230-4235
- 5 Beltowski J. Leptin and atherosclerosis. Atherosclerosis 2006; 189: 47-60
- 6 Byrne N, Hunter G, Meerkin J, Hill AP. Combining resistance and aerobic training results in greater body composition and fitness benefits than either mode separately. Obes Res 2005; 13: A138
- 7 Campos RM, Lazaretti-Castro M, Mello MT, Tock L, Silva PL, Corgosinho FC, Carnier J, Piano Ad, Sanches PL, Masquio DC, Tufik S, Dâmaso AR. Influence of visceral and subcutaneous fat in bone mineral density of obese adolescents. Arq Bras Endocrinol Metabol 2012; 56: 12-18
- 8 Caranti DA, Lazzer S, Dâmaso AR, Agosti F, Zennaro R, de Mello MT, Tufik S, Sartorio A. Prevalence and risk factors of metabolic syndrome in Brazilian and Italian obese adolescents: a comparison study. Int J ClinPract 2008; 10: 1526-1532
- 9 Carnier J, Lofrano MC, Prado WL, Caranti DA, de Piano A, Tock L, do Nascimento CM, Oyama LM, Mello MT, Tufik S, Dâmaso AR. Hormonal alteration in obese adolescents with eating disorder: effects of multidisciplinary therapy. Horm Res 2008; 70: 79-84
- 10 Centers for Disease Control and Prevention. Prevalence of overweight among children and adolescents: United States, 1999–2000. www.cdc.gov/nchs/products/pubs/pubd/hestats/overwght99.htm
- 11 Dâmaso AR, de Piano A, Sanches PL, Corgosinho F, Tock L, Oyama LM, Tock L, do Nascimento CM, Tufik S, de Mello MT. Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss. Peptides 2011; 32: 1384-1391
- 12 Davis JN, Tung A, Chak SS, Ventura EE, Byrd-Williams CE, Alexander KE, Lane CJ, Weigensberg MJ, Spruijt-Metz D, Goran MI. Aerobic and strength training reduces adiposity in overweight Latina adolescents. MedSci Sports Exerc 2009; 41: 1494-1503
- 13 de Lima Sanches P, de Mello MT, Elias N, Fonseca FA, de Piano A, Carnier J, Oyama LM, Tock L, Tufik S, Dâmaso AR. Improvement in HOMA-IR is an independent predictor of reduced carotid intima-media thickness in obese adolescents participating in an interdisciplinary weight-loss program. Hypertens Res 2011; 34: 232-238
- 14 de Piano A, de Mello MT, Sanches Pde L, da Silva PL, Campos RM, Carnier J, Corgosinho F, Foschini D, Masquio DL, Tock L, Oyama LM, do Nascimento CM, Tufik S, Dâmaso AR. Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents. Eur J Gastroenterol Hepatol 2012; 24: 1313-1324
- 15 Dutra CL, Araújo CL, Bertoldi AD. Prevalência de sobrepeso em adolescentes: um estudo de base populacional em uma cidade do Sul do Brasil. Cad Saúde Pub 2006; 22: 151-162
- 16 Elloumi M, Ben Ounis O, Makni E, Van Praagh E, Tabka Z, Lac G. Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys. Acta Paediatr 2009; 98: 1487-1493
- 17 Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O’Rahilly S. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002; 110: 1093-1103
- 18 Ferguson MA, Gutin B, Le NA, Karp W, Litaker M, Humphries M, Okuyama T, Riggs S, Owens S. Effects of exercise training and its cessation on components of the insulin resistance syndrome in obese children. Int J ObesRel Met Dis 1999; 23: 889-895
- 19 Fields DA, Goran MI. Body composition techniques and the four-compartment model in children. J Appl Physiol 2000; 89: 613-620
- 20 Foschini D, Araújo RC, Bacurau RF, De Piano A, De Almeida SS, Carnier J, Rosa TD, De Mello MT, Tufik S, Dâmaso AR. Treatment of Obese Adolescents: The Influence of Periodization Models and ACE Genotype. Obesity (Silver Spring) 2010; 18: 766-772
- 21 Goodpaster BH, Katsiaras A, Kelley DE. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes 2003; 52: 2191-2197
- 22 Gueugnon C, Mougin F, Nguyen NU, Bouhaddi M, Nicolet-Guénat M, Dumoulin G. Ghrelin and PYY levels in adolescents with severe obesity: effects of weight loss induced by long-term exercise training and modified food habits. Eur J Appl Physiol 2012; 112: 1797-1805
- 23 Gutin B, Cucuzzo N, Islam S, Smith C, Stachua ME. Physical training, lifestyle education and coronary risk factors in obese girls. Med Sci Sports Exerc 1995; 28: 19-23
- 24 Gutin B, Ramsey L, Barbeau P, Cannady W, Ferguson M, Litaker M, Owens S. Plasma leptin concentrations in obese children: changes during 4-mo periods with and without physical training. Am J ClinNutr 1999; 69: 388-394
- 25 Harriss DJ, Atkinson G. Update – Ethical standards in sport and exercise science research. Int J Sports Med 2011; 32: 819-821
- 26 Hill RJ, Davies PS. The validity of self-reported energy intake as determined using the doubly labeled water technique. Br J Nutr 2001; 85: 415-430
- 27 Institute of medicine dietary reference intakes: applications in Dietary Assessment. Washington, DC: National Academic Press; 2001
- 28 Jakicic JM, Clark K, Coleman E, Donnelly JE, Foreyt J, Melanson E, Volek J, Volpe SL. American College of Sports Medicine . Position stand on the appropriate intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc 2001; 33: 2145-2156
- 29 Kanaley JA, Fenicchia LM, Miller CS, Ploutz-Synder LL, Weinstock RS, Carhart R, Azevedo Jr JL. Resting leptin responses to acute and chronic resistance training in type 2 diabetic men and women. Int J Obes Relat Metab Disord 2001; 25: 1474-1480
- 30 Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005; 115: 500-503
- 31 Kraemer WJ, Ratamess NA, French DN. Resistance training for health and performance. Curr Sports Med Rep 2002; 1: 165-171
- 32 Lobstein T, Frelut ML. Prevalence of overweight among children in Europe. ObesRev 2003; 4: 195-200
- 33 Murer SB, Knöpfli BH, Aeberli I, Jung A, Wildhaber J, Wildhaber-Brooks J, Zimmermann MB. Baseline leptin and leptin reduction predict improvements in metabolic variables and long-term fat loss in obese children and adolescents: a prospective study of an inpatient weight-loss program. Am J Clin Nutr 2011; 93: 695-702
- 34 Oda E. The metabolic syndrome as a concept of adipose tissue disease. Hypertens Res 2008; 31: 1283-1291
- 35 Oyama LM, do Nascimento CM, Carnier J, de Piano A, Tock L, Sanches PL, Gomes FA, Tufik S, de Mello MT, Dâmaso AR. The role of anorexigenic and orexigenic neuropeptides and peripheral signals on quartiles of weight loss in obese adolescents. Neuropeptides 2010; 44: 467-474
- 36 Paz-Filho GJ, Volaco A, Suplicy HL, Radominski RB, Boguszewski CL. Decrease in leptin production by the adipose tissue in obesity associated with severe metabolic syndrome. Arq Bras Endocrinol Metabol 2009; 53: 1088-1095
- 37 Prado WL, Oyama LM, Lofrano-Prado MC, de Piano A, Stella SG, Nascimento CM, Carnier J, Caranti DA, Tock L, Tufik S, de Mello MT, Dâmaso AR. Alterations in downstream mediators involved in central control of eating behavior in obese adolescents submitted to a multidisciplinary therapy. J Adolesc Health 2011; 49: 300-305
- 38 Roberts CK, Berger JJ, Barnard RJ. Long-term effects of diet on leptin, energy intake, and activity in a model of diet-induced obesity. J Appl Physiol 2002; 93: 887-893
- 39 Romeo J, Martinez-Gomez D, Diaz LE, Gómez-Martinez S, Marti A, Martin-Matillas M, Puertollano MA, Veiga OL, Martinez JA, Wärnberg J, Zapatera B, Garagorri JM, Morandé G, Campoy C, Moreno LA, Marcos A. EVASYON Study Group . Changes in cardiometabolic risk factors, appetite-controlling hormones and cytokines after a treatment program in overweight adolescents: preliminary findings from the EVASYON study. Pediatr Diabetes 2011; 12: 372-380
- 40 Sinha A, Kling S. A review of adolescent obesity: prevalence, etiology, and treatment. Obes Surg 2008; 19: 113-120
- 41 Stanton RA. Nutrition problems in an obesogenic environment. Med J Aust 2006; 184: 76-79
- 42 Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight velocity and stages of puberty. Arch Dis Child 1976; 51: 170-179
- 43 Tock L, Prado WL, Caranti DA, Cristofalo DM, Lederman H, Fisberg M, Siqueira KO, Stella SG, Antunes HK, Cintra IP, Tufik S, de Mello MT, Dâmaso AR. Nonalcoholic fatty liver disease decrease in obese adolescents after multidisciplinary therapy. Eur J Gastroenterol Hepatol 2006; 18: 1241-1245
- 44 Tsiros MD, Sinn N, Coates AM, Howe PR, Buckley JD. Treatment of adolescent overweight and obesity. Eur J Pediatr 2008; 167: 9-16
- 45 Velloso LA. O controle hipotalâmico da fome e da termogênese: implicações no desenvolvimento da obesidade. Arq Bras Endocrinol Metab 2006; 50: 165-176
- 46 Vendrell J, Broch M, Vilarrasa N, Molina A, Gómez JM, Gutiérrez C, Simón I, Soler J, Richart C. Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. Obes Res 2004; 12: 962-971
- 47 Wang L, Mascher H, Psilander N, Blomstrand E, Sahlin K. Resistance exercise enhances the molecular signaling of mitochondrial biogenesis induced by endurance exercise in human skeletal muscle. J Appl Physiol 2011; 111: 1335-1344
- 48 Watts K, Beye P, Siafarikas A, Davis EA, Jones TW, O'Driscoll G, Green DJ. Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents. J Am Coll Card 2004; 43: 1823-1827
- 49 Winett RA, Carpinelli RN. Potential health-related benefits of resistance training. Prev Med 2001; 33: 503-513
- 50 World Health Organization . Obesity: preventing and managing the global epidemic. WHO obesity technical report series 894. Geneva: World Health Organization; 2000